View source for PMID: 17379776

{{RightTOC}}
<!--box uid=d41d8cd98f00b204e9800998ecf8427e.2140.L522384a421a09-->
<!--
******************************************************************************************
* 
*   ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. ** 
* 
****************************************************************************************** -->
{|   id="L522384a421a09"  class=" tableEdit PMID_info_table"  

|-
!align=left align='left' bgcolor='#CCCCFF' |Citation
||
'''No author listed'''  (2007) Multiple high-throughput analyses monitor the response of E. coli to perturbations. ''Science'' '''316''':593-7
|-
!align=left align='left' bgcolor='#CCCCFF' |Abstract
||
Analysis of cellular components at multiple levels of biological information can provide valuable functional insights. We performed multiple high-throughput measurements to study the response of Escherichia coli cells to genetic and environmental perturbations. Analysis of metabolic enzyme gene disruptants revealed unexpectedly small changes in messenger RNA and proteins for most disruptants. Overall, metabolite levels were also stable, reflecting the rerouting of fluxes in the metabolic network. In contrast, E. coli actively regulated enzyme levels to maintain a stable metabolic state in response to changes in growth rate. E. coli thus seems to use complementary strategies that result in a metabolic network robust against perturbations.
|-
!align=left align='left' bgcolor='#CCCCFF' |Links
||
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17379776 PubMed]
Online version:[http://dx.doi.org/10.1126/science.1132067 10.1126/science.1132067]
|-
!align=left align='left' bgcolor='#CCCCFF' |Keywords
||
Chromatography, Liquid; Computational Biology; Electrophoresis, Capillary; Electrophoresis, Gel, Two-Dimensional; Enzyme Induction; Enzyme Repression; Enzymes/genetics; Enzymes/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression; Genes, Bacterial; Mass Spectrometry; Metabolic Networks and Pathways/genetics; Mutation; Oligonucleotide Array Sequence Analysis; Proteome; RNA, Messenger/genetics; RNA, Messenger/metabolism; Systems Biology/methods; Transcription, Genetic

|- class="tableEdit_footer" 
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=d41d8cd98f00b204e9800998ecf8427e.2140.L522384a421a09&page=2140&pagename={{FULLPAGENAMEE}}&type=1&template=PMID_info_table edit table]</span> ||
|}
<!--box uid=d41d8cd98f00b204e9800998ecf8427e.2140.L522384a421a09-->
==Main Points of the Paper ==
{{LitSignificance}}

== Materials and Methods Used ==
{{LitMaterials}}

==Phenotype Annotations==
{{AnnotationTableHelp}}
<protect><!--box uid=d41d8cd98f00b204e9800998ecf8427e.2140.Y522384a44863a-->
<!--
******************************************************************************************
* 
*   ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. ** 
* 
****************************************************************************************** -->
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="Y522384a44863a"  class=" tableEdit Phenotype_Table_2"  
|- align='left' bgcolor='#CCCCFF'
!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status

|- class="tableEdit_footer" 
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=d41d8cd98f00b204e9800998ecf8427e.2140.Y522384a44863a&page=2140&pagename={{FULLPAGENAMEE}}&type=0&template=Phenotype_Table_2 edit table]</span> || || || || || || || || ||
|}
<!--box uid=d41d8cd98f00b204e9800998ecf8427e.2140.Y522384a44863a--></protect>

==Notes==

==References==
{{RefHelp}}
<references/>


[[Category:Publication]]