PMID:6094504

Citation	Fishel, RA and Kolodner, R (1984) Escherichia coli strains containing mutations in the structural gene for topoisomerase I are recombination deficient. J. Bacteriol. 160:1168-70
Abstract	Mutations in the gene encoding topoisomerase I of Escherichia coli were tested for their effect on plasmid recombination. Recombination was decreased 1,000-fold at 30 and 37 degrees C and occurred at approximately wild-type frequencies at 42 degrees C. The suppression of topA mutations at 42 degrees C did not appear to be a result of increased topoisomerase I activity at 42 degrees C.
Links	PubMed PMC215837
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Main Points of the Paper

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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: DM700 NCBI Taxon ID: 83333	Genotype of Reference Strain: topA+ Genotype of Experimental Strain : SY791 top-cys(del) 700	Reference Condition:			0000078	in vivo assay evidence	The mutation conferred a decrease in plasmid recombination. See table 2.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: DM700 NCBI Taxon ID: 83333	Genotype of Reference Strain: topA+ Genotype of Experimental Strain : SY791 top-cys(del) 700	Reference Condition:			0000078	in vivo assay evidence	The mutation conferred a decrease in supper coiling. See Figure 2.
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