Difference between revisions of "PMID: 17379776"
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| + | !align=left align='left' bgcolor='#CCCCFF' |Citation | ||
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| + | '''No author listed''' (2007) Multiple high-throughput analyses monitor the response of E. coli to perturbations. ''Science'' '''316''':593-7 | ||
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| + | !align=left align='left' bgcolor='#CCCCFF' |Abstract | ||
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| + | Analysis of cellular components at multiple levels of biological information can provide valuable functional insights. We performed multiple high-throughput measurements to study the response of Escherichia coli cells to genetic and environmental perturbations. Analysis of metabolic enzyme gene disruptants revealed unexpectedly small changes in messenger RNA and proteins for most disruptants. Overall, metabolite levels were also stable, reflecting the rerouting of fluxes in the metabolic network. In contrast, E. coli actively regulated enzyme levels to maintain a stable metabolic state in response to changes in growth rate. E. coli thus seems to use complementary strategies that result in a metabolic network robust against perturbations. | ||
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| + | !align=left align='left' bgcolor='#CCCCFF' |Links | ||
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| + | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17379776 PubMed] | ||
| + | Online version:[http://dx.doi.org/10.1126/science.1132067 10.1126/science.1132067] | ||
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| + | !align=left align='left' bgcolor='#CCCCFF' |Keywords | ||
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| + | Chromatography, Liquid; Computational Biology; Electrophoresis, Capillary; Electrophoresis, Gel, Two-Dimensional; Enzyme Induction; Enzyme Repression; Enzymes/genetics; Enzymes/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression; Genes, Bacterial; Mass Spectrometry; Metabolic Networks and Pathways/genetics; Mutation; Oligonucleotide Array Sequence Analysis; Proteome; RNA, Messenger/genetics; RNA, Messenger/metabolism; Systems Biology/methods; Transcription, Genetic | ||
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| + | ==Main Points of the Paper == | ||
| + | {{LitSignificance}} | ||
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| + | == Materials and Methods Used == | ||
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| + | ==Phenotype Annotations== | ||
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| + | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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| + | ==Notes== | ||
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| + | ==References== | ||
| + | {{RefHelp}} | ||
| + | <references/> | ||
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| + | [[Category:Publication]] | ||
Latest revision as of 13:17, 1 September 2013
| Citation |
No author listed (2007) Multiple high-throughput analyses monitor the response of E. coli to perturbations. Science 316:593-7 |
|---|---|
| Abstract |
Analysis of cellular components at multiple levels of biological information can provide valuable functional insights. We performed multiple high-throughput measurements to study the response of Escherichia coli cells to genetic and environmental perturbations. Analysis of metabolic enzyme gene disruptants revealed unexpectedly small changes in messenger RNA and proteins for most disruptants. Overall, metabolite levels were also stable, reflecting the rerouting of fluxes in the metabolic network. In contrast, E. coli actively regulated enzyme levels to maintain a stable metabolic state in response to changes in growth rate. E. coli thus seems to use complementary strategies that result in a metabolic network robust against perturbations. |
| Links |
PubMed Online version:10.1126/science.1132067 |
| Keywords |
Chromatography, Liquid; Computational Biology; Electrophoresis, Capillary; Electrophoresis, Gel, Two-Dimensional; Enzyme Induction; Enzyme Repression; Enzymes/genetics; Enzymes/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression; Genes, Bacterial; Mass Spectrometry; Metabolic Networks and Pathways/genetics; Mutation; Oligonucleotide Array Sequence Analysis; Proteome; RNA, Messenger/genetics; RNA, Messenger/metabolism; Systems Biology/methods; Transcription, Genetic |
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
See Help:AnnotationTable for details on how to edit this table.
<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
| edit table |
</protect>
Notes
References
See Help:References for how to manage references in omp dev.
