Difference between revisions of "PMID:2168148"

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'''Yoshida, H, Bogaki, M, Nakamura, M and Nakamura, S'''  (1990) Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.''Antimicrob. Agents Chemother.'' '''34''':1271-2
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!align=left  |Abstract
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Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2168148 PubMed]
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!align=left  |Keywords
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4-Quinolones; Anti-Infective Agents; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Escherichia coli; Mutation
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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{{LitMaterials}}
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==Phenotype Annotations==
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="P504cc29da19e4"  class=" tableEdit Phenotype_Table_2" 
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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a mutation or genetic difference within a strain
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*Taxon: escherichia coli
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*Strain: k-12
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*Substrain: KL16
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*Genotype of Reference Strain: gyrA
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*Genotype of Experimental Strain : gyrA mutation in N-112
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*Reference Condition:
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0006041
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increased resistance to quinolone compound
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Table 1. mutation occurred at Amino Acid 83.
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similar strains: N-118, N-119, N-51, and P-18
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==Notes==
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==References==
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<references/>
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[[Category:Publication]] [[Category:Papers referenced in the LaRossa chapter]]

Latest revision as of 13:24, 26 March 2014

Citation

Yoshida, H, Bogaki, M, Nakamura, M and Nakamura, S (1990) Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.Antimicrob. Agents Chemother. 34:1271-2

Abstract

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.

Links

PubMed

Keywords

4-Quinolones; Anti-Infective Agents; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Escherichia coli; Mutation

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Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.
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Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: escherichia coli
  • Strain: k-12
  • Substrain: KL16
  • Genotype of Reference Strain: gyrA
  • Genotype of Experimental Strain : gyrA mutation in N-112
  • Reference Condition:

0006041

increased resistance to quinolone compound

Table 1. mutation occurred at Amino Acid 83. similar strains: N-118, N-119, N-51, and P-18


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Notes

References

See Help:References for how to manage references in omp dev.

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