Difference between revisions of "PMID:2948345"
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| + | !align=left align='left' bgcolor='#CCCCFF' |Citation | ||
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| + | '''Marakusha, BI, Petrovskaia, VG and Volkovoĭ, KI''' (1986) [Isolation and characteristics of the biological and genetic properties of neamin-resistant mutants of Salmonella typhimurium and Salmonella dublin candidates for vaccine creation]. ''Zh. Mikrobiol. Epidemiol. Immunobiol.'' '''''':3-8 | ||
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| + | !align=left align='left' bgcolor='#CCCCFF' |Abstract | ||
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| + | Mutants, resistant to neamine and spectinomycin, have been isolated from S. typhimurium and S. dublin highly virulent strains. The neamine-resistant mutants can be divided into 3 classes in accordance with their sensitivity to streptomycin: sensitive, resistant to low and high concentrations of this antibiotic. The transduction analysis with the use of bacteriophage P 22 has revealed that the spectinomycin-resistant mutations under study are spc A mutations, while the mutations leading to resistance to neamine in class Near Strr 500 are nea B mutations. The mutation leading to resistance to spectinomycin (spc A) has been found to produce no changes in the virulence of salmonellae in the intraperitoneal infection of mice. The mutations leading to resistance to neamine and streptomycin (nea B and str A) have been found to decrease virulence. | ||
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| + | !align=left align='left' bgcolor='#CCCCFF' |Links | ||
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| + | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2948345 PubMed] | ||
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| + | !align=left align='left' bgcolor='#CCCCFF' |Keywords | ||
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| + | Animals; Antigens, Bacterial/analysis; Bacterial Vaccines/isolation & purification; Drug Resistance, Microbial/genetics; Mice; Mutation; Neomycin/antagonists & inhibitors; Phenotype; Salmonella/genetics; Salmonella/immunology; Salmonella/isolation & purification; Salmonella typhimurium/genetics; Salmonella typhimurium/immunology; Salmonella typhimurium/isolation & purification; Spectinomycin/antagonists & inhibitors; Streptomycin/antagonists & inhibitors; Transduction, Genetic; Virulence | ||
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| + | ==Main Points of the Paper == | ||
| + | {{LitSignificance}} | ||
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| + | == Materials and Methods Used == | ||
| + | {{LitMaterials}} | ||
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| + | ==Phenotype Annotations== | ||
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| + | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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| + | ==Notes== | ||
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| + | ==References== | ||
| + | {{RefHelp}} | ||
| + | <references/> | ||
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| + | [[Category:Publication]] | ||
| + | [[Category:Papers referenced in the LaRossa chapter]] | ||
Latest revision as of 13:36, 22 July 2015
| Citation |
'Marakusha, BI, Petrovskaia, VG and Volkovoĭ, KI (1986) [Isolation and characteristics of the biological and genetic properties of neamin-resistant mutants of Salmonella typhimurium and Salmonella dublin candidates for vaccine creation]. Zh. Mikrobiol. Epidemiol. Immunobiol. ':3-8 |
|---|---|
| Abstract |
Mutants, resistant to neamine and spectinomycin, have been isolated from S. typhimurium and S. dublin highly virulent strains. The neamine-resistant mutants can be divided into 3 classes in accordance with their sensitivity to streptomycin: sensitive, resistant to low and high concentrations of this antibiotic. The transduction analysis with the use of bacteriophage P 22 has revealed that the spectinomycin-resistant mutations under study are spc A mutations, while the mutations leading to resistance to neamine in class Near Strr 500 are nea B mutations. The mutation leading to resistance to spectinomycin (spc A) has been found to produce no changes in the virulence of salmonellae in the intraperitoneal infection of mice. The mutations leading to resistance to neamine and streptomycin (nea B and str A) have been found to decrease virulence. |
| Links | |
| Keywords |
Animals; Antigens, Bacterial/analysis; Bacterial Vaccines/isolation & purification; Drug Resistance, Microbial/genetics; Mice; Mutation; Neomycin/antagonists & inhibitors; Phenotype; Salmonella/genetics; Salmonella/immunology; Salmonella/isolation & purification; Salmonella typhimurium/genetics; Salmonella typhimurium/immunology; Salmonella typhimurium/isolation & purification; Spectinomycin/antagonists & inhibitors; Streptomycin/antagonists & inhibitors; Transduction, Genetic; Virulence |
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
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<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
| edit table |
</protect>
Notes
References
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