Difference between revisions of "PMID:7035836"
(New PMID: Page!) |
(Fill PMID: Page!) |
||
| Line 1: | Line 1: | ||
| − | + | {{RightTOC}} | |
| + | |||
| + | <!--box uid=d41d8cd98f00b204e9800998ecf8427e.6802.K55d1f832d8bf6--> | ||
| + | <!-- | ||
| + | ****************************************************************************************** | ||
| + | * | ||
| + | * ** PLEASE DON'T EDIT THIS TABLE DIRECTLY. Use the edit table link under the table. ** | ||
| + | * | ||
| + | ****************************************************************************************** --> | ||
| + | {| id="K55d1f832d8bf6" class=" tableEdit PMID_info_table" | ||
| + | |||
| + | |- | ||
| + | !align=left align='left' bgcolor='#CCCCFF' |Citation | ||
| + | || | ||
| + | '''Dabbs, ER and Looman, K''' (1981) An antibiotic dependent conditional lethal mutant with a lesion affecting transcription and translation. ''Mol. Gen. Genet.'' '''184''':224-9 | ||
| + | |- | ||
| + | !align=left align='left' bgcolor='#CCCCFF' |Abstract | ||
| + | || | ||
| + | A conditioned lethal mutant of E. coli was isolated which required the presence of either the RNA polymerase targeted antibiotic, rifampicin, or the ribosomally targeted antibiotic, kasugamycin, for survival. This mutant was characterised. The locus of the mutation responsible for the antibiotic dependent phenotype, ridA, was mapped at about 70.5 min on the chromosomal linkage map, between argR and fabE. The mutant was investigated as a candidate for a strain with a lesion in some cellular component acting on both RNA polymerase and the ribosome. A close interaction with RNA polymerase was evident from the interplay arising from the combination of ridA and various rpoB mutations as manifested in the phenotype. The ability of kasugamycin, but not other ribosomally targeted aminoglycoside antibiotics, to relieve the lethality due to the ridA mutation was an indication of the specificity in the interaction of the ridA gene product with the ribosome. | ||
| + | |- | ||
| + | !align=left align='left' bgcolor='#CCCCFF' |Links | ||
| + | || | ||
| + | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7035836 PubMed] | ||
| + | |||
| + | |- | ||
| + | !align=left align='left' bgcolor='#CCCCFF' |Keywords | ||
| + | || | ||
| + | DNA-Directed RNA Polymerases/genetics; Drug Resistance, Microbial; Escherichia coli/genetics; Genes, Lethal; Kanamycin/pharmacology; Mutation; Phenotype; Protein Biosynthesis; Rifampin/pharmacology; Transcription, Genetic | ||
| + | |||
| + | |- class="tableEdit_footer" | ||
| + | |<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=d41d8cd98f00b204e9800998ecf8427e.6802.K55d1f832d8bf6&page=6802&pagename={{FULLPAGENAMEE}}&type=1&template=PMID_info_table edit table]</span> || | ||
| + | |} | ||
| + | <noinclude> | ||
| + | <!-- OMP category tags --> | ||
| + | </noinclude> | ||
| + | <!--box uid=d41d8cd98f00b204e9800998ecf8427e.6802.K55d1f832d8bf6--> | ||
| + | |||
| + | ==Main Points of the Paper == | ||
| + | {{LitSignificance}} | ||
| + | |||
| + | == Materials and Methods Used == | ||
| + | {{LitMaterials}} | ||
| + | |||
| + | ==Phenotype Annotations== | ||
| + | {{AnnotationTableHelp}} | ||
| + | <protect><!--box uid=d41d8cd98f00b204e9800998ecf8427e.6802.Y55d1f833315f5--> | ||
| + | <!-- | ||
| + | ****************************************************************************************** | ||
| + | * | ||
| + | * ** PLEASE DON'T EDIT THIS TABLE DIRECTLY. Use the edit table link under the table. ** | ||
| + | * | ||
| + | ****************************************************************************************** --> | ||
| + | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="Y55d1f833315f5" class=" tableEdit Phenotype_Table_2" | ||
| + | |- align='left' bgcolor='#CCCCFF' | ||
| + | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
| + | |||
| + | |- class="tableEdit_footer" | ||
| + | |<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=d41d8cd98f00b204e9800998ecf8427e.6802.Y55d1f833315f5&page=6802&pagename={{FULLPAGENAMEE}}&type=0&template=Phenotype_Table_2 edit table]</span> || || || || || || || || || | ||
| + | |} | ||
| + | <noinclude> | ||
| + | <!-- OMP category tags --> | ||
| + | </noinclude> | ||
| + | <!--box uid=d41d8cd98f00b204e9800998ecf8427e.6802.Y55d1f833315f5--></protect> | ||
| + | |||
| + | ==Notes== | ||
| + | |||
| + | ==References== | ||
| + | {{RefHelp}} | ||
| + | <references/> | ||
| + | |||
| + | |||
| + | [[Category:Publication]] | ||
Latest revision as of 10:05, 17 August 2015
| Citation |
Dabbs, ER and Looman, K (1981) An antibiotic dependent conditional lethal mutant with a lesion affecting transcription and translation. Mol. Gen. Genet. 184:224-9 |
|---|---|
| Abstract |
A conditioned lethal mutant of E. coli was isolated which required the presence of either the RNA polymerase targeted antibiotic, rifampicin, or the ribosomally targeted antibiotic, kasugamycin, for survival. This mutant was characterised. The locus of the mutation responsible for the antibiotic dependent phenotype, ridA, was mapped at about 70.5 min on the chromosomal linkage map, between argR and fabE. The mutant was investigated as a candidate for a strain with a lesion in some cellular component acting on both RNA polymerase and the ribosome. A close interaction with RNA polymerase was evident from the interplay arising from the combination of ridA and various rpoB mutations as manifested in the phenotype. The ability of kasugamycin, but not other ribosomally targeted aminoglycoside antibiotics, to relieve the lethality due to the ridA mutation was an indication of the specificity in the interaction of the ridA gene product with the ribosome. |
| Links | |
| Keywords |
DNA-Directed RNA Polymerases/genetics; Drug Resistance, Microbial; Escherichia coli/genetics; Genes, Lethal; Kanamycin/pharmacology; Mutation; Phenotype; Protein Biosynthesis; Rifampin/pharmacology; Transcription, Genetic |
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
See Help:AnnotationTable for details on how to edit this table.
<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
| edit table |
</protect>
Notes
References
See Help:References for how to manage references in omp dev.
