Difference between revisions of "PMID:22001225"
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| + | {| id="B4ec30a3887347" class=" tableEdit PMID_info_table" | ||
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| + | !align=left |Citation | ||
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| + | '''Zhang, M, Zhou, Y, Li, T, Wang, H, Cheng, F, Zhou, Y, Bi, L and Zhang, XE''' (2011) MutL associates with Escherichia coli RecA and inhibits its ATPase activity.''Arch Biochem Biophys'' | ||
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| + | !align=left |Abstract | ||
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| + | Different DNA repair systems are known to cooperate to deal with DNA damage. However, the regulatory role of the cross-talk between these pathways is unclear. Here, we have shown that MutL, an essential component of mismatch repair, is a RecA-interacting protein, and that its highly conserved N-terminal domain is sufficient for this interaction. Surface plasmon resonance and capillary electrophoresis analyses revealed that MutL has little effect on RecA-ssDNA filament formation, but dose down-regulate the ATPase activity of RecA. Our findings identify a new role for MutL, and suggest its regulatory role in homologous recombination. | ||
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| + | !align=left |Links | ||
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| + | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22001225 PubMed] | ||
| + | Online version:[http://dx.doi.org/10.1016/j.abb.2011.09.013 10.1016/j.abb.2011.09.013] | ||
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| + | !align=left |Keywords | ||
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| + | |<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=2ccfb3c7bf1208312f02a69e64bfd9e0.2784.B4ec30a3887347&page=2784&pagename={{FULLPAGENAMEE}}&type=1&template=PMID_info_table edit table]</span> || | ||
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| + | <!--box uid=2ccfb3c7bf1208312f02a69e64bfd9e0.2784.B4ec30a3887347--> | ||
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| + | ==Main Points of the Paper == | ||
| + | {{LitSignificance}} | ||
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| + | == Materials and Methods Used == | ||
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| + | ==Phenotype Annotations== | ||
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| + | {| id="M4ec30a38beb02" class=" tableEdit Phenotype_Table_2" | ||
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| + | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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| + | ==Notes== | ||
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| + | ==References== | ||
| + | {{RefHelp}} | ||
| + | <references/> | ||
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| + | [[Category:Publication]] | ||
Revision as of 19:56, 15 November 2011
| Citation |
Zhang, M, Zhou, Y, Li, T, Wang, H, Cheng, F, Zhou, Y, Bi, L and Zhang, XE (2011) MutL associates with Escherichia coli RecA and inhibits its ATPase activity.Arch Biochem Biophys |
|---|---|
| Abstract |
Different DNA repair systems are known to cooperate to deal with DNA damage. However, the regulatory role of the cross-talk between these pathways is unclear. Here, we have shown that MutL, an essential component of mismatch repair, is a RecA-interacting protein, and that its highly conserved N-terminal domain is sufficient for this interaction. Surface plasmon resonance and capillary electrophoresis analyses revealed that MutL has little effect on RecA-ssDNA filament formation, but dose down-regulate the ATPase activity of RecA. Our findings identify a new role for MutL, and suggest its regulatory role in homologous recombination. |
| Links |
PubMed Online version:10.1016/j.abb.2011.09.013 |
| Keywords |
|
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
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<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
| edit table |
</protect>
Notes
References
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