Difference between revisions of "PMID:931989"
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| + | {| id="N4eec1dec87c9c" class=" tableEdit PMID_info_table" | ||
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| + | !align=left |Citation | ||
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| + | '''Schmitz, A, Schmeissner, U and Miller, JH''' (1976) Mutations affecting the quaternary structure of the lac repressor.''J. Biol. Chem.'' '''251''':3359-66 | ||
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| + | !align=left |Abstract | ||
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| + | A new class of point mutations in the lacI gene of Escherichia coli is described which results in a lac repressor that is unable to form its normal tetrameric structure. Many of these mutations result in amino acid substitutions in the neighborhood of the tyrosine at residue 269. An amber mutation derived from the codon normally specifying tyrosine 269 has been suppressed with Sul, which inserts serine in response to the amber codon. The resulting altered lac repressor is also unable to form its normal tetrameric structure and can no longer bind to the lac operator. Two missense mutations which map in the part of the gene specifying amino acid residues 210 to 216 also produce repressors unable to form tetramers. | ||
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| + | !align=left |Links | ||
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| + | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=931989 PubMed] | ||
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| + | !align=left |Keywords | ||
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| + | Bacterial Proteins; Binding Sites; Chromosome Mapping; Codon; DNA, Bacterial; Enzyme Induction; Enzyme Repression; Galactosidases; Genes; Lactose; Mutation; Protein Binding; Protein Conformation; Species Specificity; Thiogalactosides | ||
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| + | ==Main Points of the Paper == | ||
| + | {{LitSignificance}} | ||
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| + | == Materials and Methods Used == | ||
| + | {{LitMaterials}} | ||
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| + | ==Phenotype Annotations== | ||
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| + | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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| + | ==Notes== | ||
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| + | ==References== | ||
| + | {{RefHelp}} | ||
| + | <references/> | ||
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| + | [[Category:Publication]] | ||
Latest revision as of 23:43, 16 December 2011
| Citation |
Schmitz, A, Schmeissner, U and Miller, JH (1976) Mutations affecting the quaternary structure of the lac repressor.J. Biol. Chem. 251:3359-66 |
|---|---|
| Abstract |
A new class of point mutations in the lacI gene of Escherichia coli is described which results in a lac repressor that is unable to form its normal tetrameric structure. Many of these mutations result in amino acid substitutions in the neighborhood of the tyrosine at residue 269. An amber mutation derived from the codon normally specifying tyrosine 269 has been suppressed with Sul, which inserts serine in response to the amber codon. The resulting altered lac repressor is also unable to form its normal tetrameric structure and can no longer bind to the lac operator. Two missense mutations which map in the part of the gene specifying amino acid residues 210 to 216 also produce repressors unable to form tetramers. |
| Links | |
| Keywords |
Bacterial Proteins; Binding Sites; Chromosome Mapping; Codon; DNA, Bacterial; Enzyme Induction; Enzyme Repression; Galactosidases; Genes; Lactose; Mutation; Protein Binding; Protein Conformation; Species Specificity; Thiogalactosides |
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
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<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
| edit table |
</protect>
Notes
References
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