Difference between revisions of "PMID:230407"

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'''Daniel, J and Danchin, A'''  (1979) Involvement of cyclic AMP and its receptor protein in the sensitivity of Escherichia coli K 12 toward serine: excretion of 2-ketobutyrate, a precursor of isoleucine.''Mol. Gen. Genet.'' '''176''':343-50
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!align=left  |Abstract
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A relationship between serine-induced growth sensitivity and the cAMP-CAP complex is established. Mutants of Escherichia coli K 12 deficient either in the cya or crp gene function exhibit a resistant phenotype on serine media although they harbor a relA allele normally leading to sensitivity toward serine. The presence of a crp allele in a cya delta relA background restores the sensitivity phenotype, while the analysis of serine resistant mutants selected from a crp cya delta relA strain shows that the mutation leading to resistance is located at, or very near, the crp gene, giving a more or less Crp- phenotype. In addition crp cya delta relA strains excrete large quantities of 2-ketobutyrate when grown on glucose M63 medium. This excretion is unambiguously linked to the presence of the crp allele and is correlated with an enhanced threonine deaminase activity. Besides, the complex regulation exerted on the acetolactate synthase activities is discussed.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=230407 PubMed]
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!align=left  |Keywords
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Butyrates; Cyclic AMP; Escherichia coli; Isoleucine; Mutation; Phenotype; Receptors, Cyclic AMP; Serine; Transduction, Genetic
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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{{LitMaterials}}
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==Phenotype Annotations==
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain:
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&p=mapview&p=has_linkout&p=blast_url&p=genome_blast&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''crp relA''
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*Genotype of Experimental Strain : ''crp <sup>  -</sup> relA<sup>  +</sup>''
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*Reference Condition:
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ECO:0000182
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in vitro culture assay data
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Deficient mutants in relA backgroumd, were found to be resistant to smg (serine+methionine+glycine)
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: BM6163
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&p=mapview&p=has_linkout&p=blast_url&p=genome_blast&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''cya crp''
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*Genotype of Experimental Strain : ''cya(del) crp<nowiki>*</nowiki>''
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*Reference Condition: ''relA<sup>  +</sup>''
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ECO:0000182
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in vitro culture assay data
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crp allele that modified cyclic AMP receptor proteins, which acts independently of cyclic AMP, is resistant to smg (serine+methionine+glycine) in a relA background.
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==Notes==
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waiting on new omp terms. Resistant to serine
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==References==
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{{RefHelp}}
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<references/>
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[[Category:Publication]] [[Category:Papers referenced in the LaRossa chapter]] [[Category:LaRossa citations that need review]]

Latest revision as of 19:14, 5 April 2012

Citation

Daniel, J and Danchin, A (1979) Involvement of cyclic AMP and its receptor protein in the sensitivity of Escherichia coli K 12 toward serine: excretion of 2-ketobutyrate, a precursor of isoleucine.Mol. Gen. Genet. 176:343-50

Abstract

A relationship between serine-induced growth sensitivity and the cAMP-CAP complex is established. Mutants of Escherichia coli K 12 deficient either in the cya or crp gene function exhibit a resistant phenotype on serine media although they harbor a relA allele normally leading to sensitivity toward serine. The presence of a crp allele in a cya delta relA background restores the sensitivity phenotype, while the analysis of serine resistant mutants selected from a crp cya delta relA strain shows that the mutation leading to resistance is located at, or very near, the crp gene, giving a more or less Crp- phenotype. In addition crp cya delta relA strains excrete large quantities of 2-ketobutyrate when grown on glucose M63 medium. This excretion is unambiguously linked to the presence of the crp allele and is correlated with an enhanced threonine deaminase activity. Besides, the complex regulation exerted on the acetolactate synthase activities is discussed.

Links

PubMed

Keywords

Butyrates; Cyclic AMP; Escherichia coli; Isoleucine; Mutation; Phenotype; Receptors, Cyclic AMP; Serine; Transduction, Genetic

edit table

Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.
<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain:
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: crp relA
  • Genotype of Experimental Strain : crp - relA +
  • Reference Condition:

ECO:0000182

in vitro culture assay data

Deficient mutants in relA backgroumd, were found to be resistant to smg (serine+methionine+glycine)

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: BM6163
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: cya crp
  • Genotype of Experimental Strain : cya(del) crp*
  • Reference Condition: relA +

ECO:0000182

in vitro culture assay data

crp allele that modified cyclic AMP receptor proteins, which acts independently of cyclic AMP, is resistant to smg (serine+methionine+glycine) in a relA background.


edit table

</protect>

Notes

waiting on new omp terms. Resistant to serine

References

See Help:References for how to manage references in omp dev.

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