Difference between revisions of "PMID:372756"

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{|  id="V4f7f5e4fb76d5"  class=" tableEdit PMID_info_table" 
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!align=left  |Citation
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'''Hummel, H, Piepersberg, W and Böck, A'''  (1979) Analysis of lincomycin resistance mutations in Escherichia coli.''Mol. Gen. Genet.'' '''169''':345-7
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!align=left  |Abstract
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High level lincomycin resistant strains of Escherichia coli were isolated and screened for altered ribosomal proteins and functions. Amongst 58 strains investigated by electrophoresis one had an altered ribosomal protein S7, another one a mutated L14 and two showed altered L15 proteins. A correlation between these alterations and lincomycin resistant growth could not be demonstrated by genetic analysis for any of the mutants. In vitro, however, extracts from the two L15 mutants were less sensitive to inhibition by the drug. A gene locus (linR) responsible for the lincomycin resistance phenotype was mapped at min 30 of the Escherichia coli chromosome near tyrR; it seems to be identical to the previously described linB locus (Apirion, 1967); however, in contrast to these reports it does not seem to alter any ribosomal function.
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!align=left  |Links
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=372756 PubMed]
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!align=left  |Keywords
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Bacterial Proteins; Drug Resistance, Microbial; Electrophoresis; Escherichia coli; Lincomycin; Mutation; Phenotype; Ribosomal Proteins
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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{{LitMaterials}}
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==Phenotype Annotations==
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{{AnnotationTableHelp}}
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{|  id="K4f7f5e5005032"  class=" tableEdit Phenotype_Table_2" 
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: LE2-10
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&p=mapview&p=has_linkout&p=blast_url&p=genome_blast&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''rpsG''
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*Genotype of Experimental Strain : ''rpsG'' in strain LE2-10
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*Reference Condition:
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OMP:0000276
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increased resistance to antibiotics
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ECO:0000182
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in vitro culture assay data
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Resistant to lincomycin
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: LE2-12
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&p=mapview&p=has_linkout&p=blast_url&p=genome_blast&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''rplN''
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*Genotype of Experimental Strain : ''rplN''
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*Reference Condition:
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OMP:0000276
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increased resistance to antibiotics
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|
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ECO:0000182
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|
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in vitro culture assay data
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|
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Resistance to Lincomycin
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|-
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: LE2-7 and LE5-1
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&p=mapview&p=has_linkout&p=blast_url&p=genome_blast&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''rplO''
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*Genotype of Experimental Strain : ''rplO''
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*Reference Condition:
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OMP:0000276
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increased resistance to antibiotics
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|
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ECO:0000182
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|
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in vitro culture assay data
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Resistance to Lincomycin
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|- class="tableEdit_footer"
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==Notes==
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==References==
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{{RefHelp}}
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<references/>
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[[Category:Publication]] [[Category:Papers referenced in the LaRossa chapter]]

Latest revision as of 14:26, 9 April 2012

Citation

Hummel, H, Piepersberg, W and Böck, A (1979) Analysis of lincomycin resistance mutations in Escherichia coli.Mol. Gen. Genet. 169:345-7

Abstract

High level lincomycin resistant strains of Escherichia coli were isolated and screened for altered ribosomal proteins and functions. Amongst 58 strains investigated by electrophoresis one had an altered ribosomal protein S7, another one a mutated L14 and two showed altered L15 proteins. A correlation between these alterations and lincomycin resistant growth could not be demonstrated by genetic analysis for any of the mutants. In vitro, however, extracts from the two L15 mutants were less sensitive to inhibition by the drug. A gene locus (linR) responsible for the lincomycin resistance phenotype was mapped at min 30 of the Escherichia coli chromosome near tyrR; it seems to be identical to the previously described linB locus (Apirion, 1967); however, in contrast to these reports it does not seem to alter any ribosomal function.

Links

PubMed

Keywords

Bacterial Proteins; Drug Resistance, Microbial; Electrophoresis; Escherichia coli; Lincomycin; Mutation; Phenotype; Ribosomal Proteins

edit table

Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.
<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: LE2-10
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: rpsG
  • Genotype of Experimental Strain : rpsG in strain LE2-10
  • Reference Condition:

OMP:0000276

increased resistance to antibiotics

ECO:0000182

in vitro culture assay data

Resistant to lincomycin

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: LE2-12
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: rplN
  • Genotype of Experimental Strain : rplN
  • Reference Condition:

OMP:0000276

increased resistance to antibiotics

ECO:0000182

in vitro culture assay data

Resistance to Lincomycin

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: LE2-7 and LE5-1
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: rplO
  • Genotype of Experimental Strain : rplO
  • Reference Condition:

OMP:0000276

increased resistance to antibiotics

ECO:0000182

in vitro culture assay data

Resistance to Lincomycin


edit table

</protect>

Notes

References

See Help:References for how to manage references in omp dev.

Retrieved from "http://bcbp-ftq4xm2.biobio.tamu.edu/omp/dev/index.php?title=PMID:372756&oldid=6774"