PMID:372756

Citation	Hummel, H, Piepersberg, W and Böck, A (1979) Analysis of lincomycin resistance mutations in Escherichia coli.Mol. Gen. Genet. 169:345-7
Abstract	High level lincomycin resistant strains of Escherichia coli were isolated and screened for altered ribosomal proteins and functions. Amongst 58 strains investigated by electrophoresis one had an altered ribosomal protein S7, another one a mutated L14 and two showed altered L15 proteins. A correlation between these alterations and lincomycin resistant growth could not be demonstrated by genetic analysis for any of the mutants. In vitro, however, extracts from the two L15 mutants were less sensitive to inhibition by the drug. A gene locus (linR) responsible for the lincomycin resistance phenotype was mapped at min 30 of the Escherichia coli chromosome near tyrR; it seems to be identical to the previously described linB locus (Apirion, 1967); however, in contrast to these reports it does not seem to alter any ribosomal function.
Links	PubMed
Keywords	Bacterial Proteins; Drug Resistance, Microbial; Electrophoresis; Escherichia coli; Lincomycin; Mutation; Phenotype; Ribosomal Proteins
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Main Points of the Paper

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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: LE2-10 NCBI Taxon ID: 83333	Genotype of Reference Strain: rpsG Genotype of Experimental Strain : rpsG in strain LE2-10	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	Resistant to lincomycin
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: LE2-12 NCBI Taxon ID: 83333	Genotype of Reference Strain: rplN Genotype of Experimental Strain : rplN	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	Resistance to Lincomycin
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: LE2-7 and LE5-1 NCBI Taxon ID: 83333	Genotype of Reference Strain: rplO Genotype of Experimental Strain : rplO	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	Resistance to Lincomycin
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