Difference between revisions of "PMID:4555418"

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{|  id="V4f908867dafa2"  class=" tableEdit PMID_info_table" 
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'''Venkateswaran, PS and Wu, HC'''  (1972) Isolation and characterization of a phosphonomycin-resistant mutant of Escherichia coli K-12.''J. Bacteriol.'' '''110''':935-44
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!align=left  |Abstract
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A mutant was isolated from Escherichia coli K-12 which showed increased resistance towards phosphonomycin, a new bactericidal antibiotic recently isolated from strains of Streptomyces. Evidence is presented which suggests that this mutant is resistant to lysis by phosphonomycin because of a lower affinity of phosphoenolpyruvate: uridine diphospho-N-acetylglucosamine enolpyruvyl transferase for this antibiotic. This mutant was also found to be temperature-sensitive in growth. At 42 C mutant cells grew poorly, and the rate of incorporation of (3)H-diaminopimelic acid into trichloroacetic acid-insoluble material was also greatly reduced. Genetic studies indicate that the increased resistance toward phosphonomycin and temperature sensitivity in growth of this mutant are probably the consequences of a single mutation.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4555418 PubMed]
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!align=left  |Keywords
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Anti-Bacterial Agents; Carbon Isotopes; Cell Wall; Chromatography, Paper; Culture Media; Drug Resistance, Microbial; Escherichia coli; Genetics, Microbial; Glucose; Glucosephosphates; Glycerophosphates; Microscopy, Phase-Contrast; Mutation; Phosphoenolpyruvate; Phosphotransferases; Pimelic Acids; Temperature; Tritium
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==Main Points of the Paper ==
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== Materials and Methods Used ==
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==Phenotype Annotations==
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==Notes==
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==References==
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[[Category:Publication]]

Revision as of 16:49, 19 April 2012

Citation

Venkateswaran, PS and Wu, HC (1972) Isolation and characterization of a phosphonomycin-resistant mutant of Escherichia coli K-12.J. Bacteriol. 110:935-44

Abstract

A mutant was isolated from Escherichia coli K-12 which showed increased resistance towards phosphonomycin, a new bactericidal antibiotic recently isolated from strains of Streptomyces. Evidence is presented which suggests that this mutant is resistant to lysis by phosphonomycin because of a lower affinity of phosphoenolpyruvate: uridine diphospho-N-acetylglucosamine enolpyruvyl transferase for this antibiotic. This mutant was also found to be temperature-sensitive in growth. At 42 C mutant cells grew poorly, and the rate of incorporation of (3)H-diaminopimelic acid into trichloroacetic acid-insoluble material was also greatly reduced. Genetic studies indicate that the increased resistance toward phosphonomycin and temperature sensitivity in growth of this mutant are probably the consequences of a single mutation.

Links

PubMed

Keywords

Anti-Bacterial Agents; Carbon Isotopes; Cell Wall; Chromatography, Paper; Culture Media; Drug Resistance, Microbial; Escherichia coli; Genetics, Microbial; Glucose; Glucosephosphates; Glycerophosphates; Microscopy, Phase-Contrast; Mutation; Phosphoenolpyruvate; Phosphotransferases; Pimelic Acids; Temperature; Tritium

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Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

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<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status
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</protect>

Notes

References

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