Difference between revisions of "PMID:794878"

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{|  id="T504cb59ecfa64"  class=" tableEdit PMID_info_table" 
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'''Gellert, M, O'Dea, MH, Itoh, T and Tomizawa, J'''  (1976) Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.''Proc. Natl. Acad. Sci. U.S.A.'' '''73''':4474-8
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!align=left  |Abstract
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Novobiocin and coumermycin are known to inhibit the replication of DNA iing of DNA catalyzed by E. coli DNA gyrase, a recently discovered enzyme that introduces negative superhelical turns into covalently circular DNA. The activity of DNA gyrase purified from a coumermycin-resistant mutant strain is resistant to both drugs. The inhibition by novobiocin of colicin E1 plasmid DNA replication in a cell-free system is partially relieved by adding resistant DNA gyrase. Both in the case of coliclls. DNA molecules which are converted to the covalently circular form in thepresence of coumermycin remain relaxed, instead of achieving their normal supercoiled conformation. We conclude that DNA gyrase controls the supercoiling of DNA in E. coli.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=794878 PubMed]
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!align=left  |Keywords
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Anti-Bacterial Agents; Colicins; Coumarins; DNA Replication; DNA, Bacterial; DNA, Circular; DNA, Viral; Escherichia coli; Mutation; Novobiocin; Nucleic Acid Conformation; Plasmids; Pyrroles
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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==Phenotype Annotations==
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==Notes==
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==References==
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[[Category:Publication]]

Revision as of 10:28, 9 September 2012

Citation

Gellert, M, O'Dea, MH, Itoh, T and Tomizawa, J (1976) Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.Proc. Natl. Acad. Sci. U.S.A. 73:4474-8

Abstract

Novobiocin and coumermycin are known to inhibit the replication of DNA iing of DNA catalyzed by E. coli DNA gyrase, a recently discovered enzyme that introduces negative superhelical turns into covalently circular DNA. The activity of DNA gyrase purified from a coumermycin-resistant mutant strain is resistant to both drugs. The inhibition by novobiocin of colicin E1 plasmid DNA replication in a cell-free system is partially relieved by adding resistant DNA gyrase. Both in the case of coliclls. DNA molecules which are converted to the covalently circular form in thepresence of coumermycin remain relaxed, instead of achieving their normal supercoiled conformation. We conclude that DNA gyrase controls the supercoiling of DNA in E. coli.

Links

PubMed

Keywords

Anti-Bacterial Agents; Colicins; Coumarins; DNA Replication; DNA, Bacterial; DNA, Circular; DNA, Viral; Escherichia coli; Mutation; Novobiocin; Nucleic Acid Conformation; Plasmids; Pyrroles

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Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

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<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status
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</protect>

Notes

References

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