PMID:23224554

Citation	Al Mamun, AA , Lombardo, MJ , Shee, C , Lisewski, AM , Gonzalez, C , Lin, D , Nehring, RB , Saint-Ruf, C , Gibson, JL , Frisch, RL , Lichtarge, O , Hastings, PJ and Rosenberg, SM (2012) Identity and function of a large gene network underlying mutagenic repair of DNA breaks. Science 338:1344-8
Abstract	Mechanisms of DNA repair and mutagenesis are defined on the basis of relatively few proteins acting on DNA, yet the identities and functions of all proteins required are unknown. Here, we identify the network that underlies mutagenic repair of DNA breaks in stressed Escherichia coli and define functions for much of it. Using a comprehensive screen, we identified a network of ≥93 genes that function in mutation. Most operate upstream of activation of three required stress responses (RpoS, RpoE, and SOS, key network hubs), apparently sensing stress. The results reveal how a network integrates mutagenic repair into the biology of the cell, show specific pathways of environmental sensing, demonstrate the centrality of stress responses, and imply that these responses are attractive as potential drug targets for blocking the evolution of pathogens.
Links	PubMed Online version:10.1126/science.1226683
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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: srlA+ Genotype of Experimental Strain : srlA777(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ybjT+ Genotype of Experimental Strain : ybjT770(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: treR+ Genotype of Experimental Strain : treR788(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yjcC Genotype of Experimental Strain : yjcC755(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yjcC Genotype of Experimental Strain : yjcC750::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ytjB Genotype of Experimental Strain : ytjB(P)::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: arcA Genotype of Experimental Strain : arcA(P)::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ligA Genotype of Experimental Strain : ligA(P)::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: apaG Genotype of Experimental Strain : apaG762(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: phoU Genotype of Experimental Strain : phoU755(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ihfA+ Genotype of Experimental Strain : ihfA786(del)FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqgE+ Genotype of Experimental Strain : yqgE723(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yfjL+ Genotype of Experimental Strain : yfjL(P)::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: lrp+ Genotype of Experimental Strain : Irp787(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: malL+ Genotype of Experimental Strain : mall768(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: acrA+ Genotype of Experimental Strain : acrA748(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: trxB+ Genotype of Experimental Strain : trxB786(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: fre+ Genotype of Experimental Strain : fre784(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cspC+ Genotype of Experimental Strain : cspC747(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: barA+ Genotype of Experimental Strain : barA784(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ifhA+ Genotype of Experimental Strain : ihfA786(del)FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). A strong mutation, SIM was reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiA+ Genotype of Experimental Strain : ubiA::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiE+ Genotype of Experimental Strain : ubiE778(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hfq+ Genotype of Experimental Strain : hfq722(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoJ+ Genotype of Experimental Strain : nuoJ762(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoC+ Genotype of Experimental Strain : nuoC768(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoL+ Genotype of Experimental Strain : nuoL760(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiH Genotype of Experimental Strain : ubiH758(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: dsbA Genotype of Experimental Strain : dsbA723(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoH Genotype of Experimental Strain : nuoH764(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yifE Genotype of Experimental Strain : yifE782(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: rppH Genotype of Experimental Strain : rppH754(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: rpoE Genotype of Experimental Strain : rpoE2072::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: prc Genotype of Experimental Strain : prc755(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: lon Genotype of Experimental Strain : lon725(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nagC Genotype of Experimental Strain : nagC725(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoG Genotype of Experimental Strain : nuoG::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: rbsK Genotype of Experimental Strain : rbsK781(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pepP Genotype of Experimental Strain : pepP759(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hemL Genotype of Experimental Strain : hemL::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pepP Genotype of Experimental Strain : pepP759(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pstB Genotype of Experimental Strain : pstB756(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiX Genotype of Experimental Strain : ubiX732(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hdfR Genotype of Experimental Strain : hdfR785(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: zncC Genotype of Experimental Strain : znuC783(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoK Genotype of Experimental Strain : nuoK761(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgi Genotype of Experimental Strain : pgi721(del)FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ygfA Genotype of Experimental Strain : ygfA763(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yigP Genotype of Experimental Strain : yigP::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: mdh Genotype of Experimental Strain : mdh761(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyaA Genotype of Experimental Strain : cyaA751(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: tatC Genotype of Experimental Strain : tatC781(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: glnK Genotype of Experimental Strain : glnK736(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: sdhB Genotype of Experimental Strain : sdhB774(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqiC Genotype of Experimental Strain : yqiC737(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: apaH Genotype of Experimental Strain : apaH761(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoA Genotype of Experimental Strain : cyoA789(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hscB Genotype of Experimental Strain : hscB773(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoD Genotype of Experimental Strain : cyoD786(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: dsbC Genotype of Experimental Strain : dsbC744(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pstC Genotype of Experimental Strain : pstC758(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: znuA Genotype of Experimental Strain : znuA782(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgl Genotype of Experimental Strain : pgl739(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: argR Genotype of Experimental Strain : argR762(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: fru Genotype of Experimental Strain : fruR786(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: speE Genotype of Experimental Strain : speE739(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: sdhD Genotype of Experimental Strain : sdhD772(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cysD Genotype of Experimental Strain : cysD(P)::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: speD+ Genotype of Experimental Strain : speD738(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: proL Genotype of Experimental Strain : proL::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: lipB Genotype of Experimental Strain : lipB769(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: znuA782 Genotype of Experimental Strain : znuA782(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiD Genotype of Experimental Strain : ubiD::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yhhK Genotype of Experimental Strain : yhhK::Tn10dCam	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: metJ Genotype of Experimental Strain : metJ725(del)::FRTKanFRT	Reference Condition:			0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hscB Genotype of Experimental Strain : hscB773(del)::FRT	Reference Condition:			0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yjcC Genotype of Experimental Strain : yjcC755(del)::FRTKanFRT	Reference Condition:					An increase in UV Sensitivity. Supplemental Table S1 & S7.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ligA Genotype of Experimental Strain : ligA(P)::Tn10dCam	Reference Condition:					An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqgE Genotype of Experimental Strain : yqgE723(del)::FRTKanFRT	Reference Condition:					An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqgE Genotype of Experimental Strain : yqgE723(del)::FRTKanFRT	Reference Condition:					An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: uvrY Genotype of Experimental Strain : uvrY760(del)::FRT	Reference Condition:					An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pstB Genotype of Experimental Strain : pstB756(del)::FRT	Reference Condition:					An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgI Genotype of Experimental Strain : pgl739(del)::FRT	Reference Condition:					An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ldcA Genotype of Experimental Strain : idcA782(del)::FRTKanFRT	Reference Condition:					An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR6039 NCBI Taxon ID: 83333	Genotype of Reference Strain: uvrY Genotype of Experimental Strain : SMR6039 uvrY760(del)::FRTkanFRT	Reference Condition:					The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR6039 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgi Genotype of Experimental Strain : SMR6039 pgi721(del)FRTKanFRT	Reference Condition:					The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR6039 NCBI Taxon ID: 83333	Genotype of Reference Strain: lexA Genotype of Experimental Strain : SMR6039 lexA3(Ind-)MalB::Tn9	Reference Condition:					The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR6039 NCBI Taxon ID: 83333	Genotype of Reference Strain: recB Genotype of Experimental Strain : SMR6039 recB(del)::Kan	Reference Condition:					The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR11941 NCBI Taxon ID: 83333	Genotype of Reference Strain: recC Genotype of Experimental Strain : SMR6039 recC::Tn10DCam	Reference Condition:					The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT rpoS+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT rpoS746(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT apaH+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT apaH761(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT cspC+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT cspC747(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoA+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT cyoA789(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT cyoD+ Genotype of Experimental Strain : SMR4562 cyoD786(del)::FRTKanFRT yiaG-yfp FRTcatFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT fre+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT fre784(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT glnK+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT glnK736(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT hdfR+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRT hemL::Tn10dCam	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: hfq+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT hfq722(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT metJ+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT metJ725(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT hscB+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT hscB773(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: mdh+ Genotype of Experimental Strain : SMR4562 mdh761(del)::FRTKanFRT yiaG-yfp FRTcatFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoC+ Genotype of Experimental Strain : SMR4562 nuoC768(del)::FRT yiaG-yfp FRTcatFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoG+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRT nuoG::Tn10dCam	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoH+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT nuoH764(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: yiaG-yfp FRTcatFRT nuoJ+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT nuoJ762(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: yiaG-yfp FRTcatFRT nuoK+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT nuoK761(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: yiaG-yfp FRTcatFRT nuoL+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT nuoL760(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: yiaG-yfp FRTcatFRT pgi+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT pgi721(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT rbsK+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT rbsK781(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT sdhD+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT sdhD772::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT sdhB+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT sdhB774(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT speD+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT speD738(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT speE+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT speE739(del)::FRTKanFRT	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 (=SMR4562 yiaG-yfp FRTcatFRT) NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT ubiA+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRT ubiA::Tn10dCam	Reference Condition:		Decreased Sigma S Activity			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
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Notes

• Reminder to indicate Stationary phase where it is necessary on both ompwiki and ecoliwiki

References

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