Difference between revisions of "PMID:19103924"

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{|  id="O4d7e910542698"  class=" tableEdit PMID_info_table" 
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!align=left  |Citation
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'''Timmermans, J and Van Melderen, L'''  (2009) Conditional essentiality of the csrA gene in Escherichia coli.''J. Bacteriol.'' '''191''':1722-4
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!align=left  |Abstract
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CsrA is a global posttranscriptional regulator of numerous physiological processes, such as glycogenesis and glycolysis. Here, we show that the csrA gene of Escherichia coli is essential for growth on LB and on synthetic medium containing glycolytic carbon sources. However, csrA is not necessary for growth on synthetic medium containing pyruvate, showing that the Krebs cycle is functional in the csrA::cat deletion mutant. Deletion of the glgCAP operon in the csrA::cat mutant restored the ability to grow on LB and on synthetic medium containing glycolytic carbon sources, showing that growth inhibition is due to an excess of glycogen synthesis.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19103924 PubMed]
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Online version:[http://dx.doi.org/10.1128/JB.01573-08 10.1128/JB.01573-08]
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!align=left  |Keywords
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Culture Media; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Gene Expression Regulation, Bacterial; Genes, Essential; Glycogen; Glycogen Storage Disease; Glycolysis; RNA-Binding Proteins; Repressor Proteins
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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{{LitMaterials}}
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==Phenotype Annotations==
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{|  id="Z4d7e91054b573"  class=" tableEdit PMID_Phenotype_table" 
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!|Species!!Taxon ID!!Strain!!Gene (if known)!!OMP!!Phenotype!!Details!!Evidence!!Notes
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''Escherichia coli''
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csrA
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no growth on LB
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Growth
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Figure 3
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''Escherichia coli''
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csrA
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no growth on synthetic media containing glycolytic carbon sources
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Growth
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Figure 3
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''Escherichia coli''
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csrA
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growth on synthetic media containing pyruvate
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Growth
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Figure 3
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==Notes==
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==References==
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{{RefHelp}}
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<references/>
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[[Category:Publication]]
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[[Category:To Be Converted]]

Latest revision as of 12:09, 22 June 2011

Citation

Timmermans, J and Van Melderen, L (2009) Conditional essentiality of the csrA gene in Escherichia coli.J. Bacteriol. 191:1722-4

Abstract

CsrA is a global posttranscriptional regulator of numerous physiological processes, such as glycogenesis and glycolysis. Here, we show that the csrA gene of Escherichia coli is essential for growth on LB and on synthetic medium containing glycolytic carbon sources. However, csrA is not necessary for growth on synthetic medium containing pyruvate, showing that the Krebs cycle is functional in the csrA::cat deletion mutant. Deletion of the glgCAP operon in the csrA::cat mutant restored the ability to grow on LB and on synthetic medium containing glycolytic carbon sources, showing that growth inhibition is due to an excess of glycogen synthesis.

Links

PubMed Online version:10.1128/JB.01573-08

Keywords

Culture Media; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Gene Expression Regulation, Bacterial; Genes, Essential; Glycogen; Glycogen Storage Disease; Glycolysis; RNA-Binding Proteins; Repressor Proteins

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Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.
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Species Taxon ID Strain Gene (if known) OMP Phenotype Details Evidence Notes

Escherichia coli

csrA

no growth on LB

Growth

Figure 3

Escherichia coli

csrA

no growth on synthetic media containing glycolytic carbon sources

Growth

Figure 3

Escherichia coli

csrA

growth on synthetic media containing pyruvate

Growth

Figure 3

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</protect>

Notes

References

See Help:References for how to manage references in omp dev.

Retrieved from "http://bcbp-ftq4xm2.biobio.tamu.edu/omp/dev/index.php?title=PMID:19103924&oldid=5140"