Difference between revisions of "PMID:16970815"

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'''Crowley, DJ, Boubriak, I, Berquist, BR, Clark, M, Richard, E, Sullivan, L, DasSarma, S and McCready, S'''  (2006) The uvrA, uvrB and uvrC genes are required for repair of ultraviolet light induced DNA photoproducts in Halobacterium sp. NRC-1.''Saline Syst.'' '''2''':11
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!align=left  |Abstract
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Sequenced archaeal genomes contain a variety of bacterial and eukaryotic DNA repair gene homologs, but relatively little is known about how these microorganisms actually perform DNA repair. At least some archaea, including the extreme halophile Halobacterium sp. NRC-1, are able to repair ultraviolet light (UV) induced DNA damage in the absence of light-dependent photoreactivation but this 'dark' repair capacity remains largely uncharacterized. Halobacterium sp. NRC-1 possesses homologs of the bacterial uvrA, uvrB, and uvrC nucleotide excision repair genes as well as several eukaryotic repair genes and it has been thought that multiple DNA repair pathways may account for the high UV resistance and dark repair capacity of this model halophilic archaeon. We have carried out a functional analysis, measuring repair capability in uvrA, uvrB and uvrC deletion mutants.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16970815 PubMed]
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Online version:[http://dx.doi.org/10.1186/1746-1448-2-11 10.1186/1746-1448-2-11]
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!align=left  |Keywords
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==Main Points of the Paper ==
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{{LitSignificance}}
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== Materials and Methods Used ==
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{{LitMaterials}}
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==Phenotype Annotations==
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{{AnnotationTableHelp}}
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{|  id="R4f3d8f22f01fb"  class=" tableEdit Phenotype_Table_2" 
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain:
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/taxonomy?term=83333 83333]
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*Genotype of Reference Strain: ''uvrA''
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*Genotype of Experimental Strain : ''uvrA(del)''
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*Reference Condition:
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OMP:0000270
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absence of growth
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ECO:0000094
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biological assay data
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Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, figure 2.
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain:
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/taxonomy?term=83333 83333]
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*Genotype of Reference Strain: ''uvrB''
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*Genotype of Experimental Strain : ''uvrB(del)''
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*Reference Condition:
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0000270
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absence of growth
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0000094
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biological assay data
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Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, figure 2.
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain:
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/taxonomy?term=83333 83333]
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*Genotype of Reference Strain: ''uvrC''
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*Genotype of Experimental Strain : ''uvrC(del)''
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*Reference Condition:
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OMP:0000270
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absence of growth
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ECO:0000094
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biological assay data
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Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, fig 2.
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==Notes==
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==References==
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{{RefHelp}}
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<references/>
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[[Category:Publication]]

Latest revision as of 13:02, 17 February 2012

Citation

Crowley, DJ, Boubriak, I, Berquist, BR, Clark, M, Richard, E, Sullivan, L, DasSarma, S and McCready, S (2006) The uvrA, uvrB and uvrC genes are required for repair of ultraviolet light induced DNA photoproducts in Halobacterium sp. NRC-1.Saline Syst. 2:11

Abstract

Sequenced archaeal genomes contain a variety of bacterial and eukaryotic DNA repair gene homologs, but relatively little is known about how these microorganisms actually perform DNA repair. At least some archaea, including the extreme halophile Halobacterium sp. NRC-1, are able to repair ultraviolet light (UV) induced DNA damage in the absence of light-dependent photoreactivation but this 'dark' repair capacity remains largely uncharacterized. Halobacterium sp. NRC-1 possesses homologs of the bacterial uvrA, uvrB, and uvrC nucleotide excision repair genes as well as several eukaryotic repair genes and it has been thought that multiple DNA repair pathways may account for the high UV resistance and dark repair capacity of this model halophilic archaeon. We have carried out a functional analysis, measuring repair capability in uvrA, uvrB and uvrC deletion mutants.

Links

PubMed Online version:10.1186/1746-1448-2-11

Keywords


edit table

Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.
<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain:
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: uvrA
  • Genotype of Experimental Strain : uvrA(del)
  • Reference Condition:

OMP:0000270

absence of growth

ECO:0000094

biological assay data

Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, figure 2.

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain:
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: uvrB
  • Genotype of Experimental Strain : uvrB(del)
  • Reference Condition:

0000270

absence of growth

0000094

biological assay data

Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, figure 2.

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain:
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: uvrC
  • Genotype of Experimental Strain : uvrC(del)
  • Reference Condition:

OMP:0000270

absence of growth

ECO:0000094

biological assay data

Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, fig 2.


edit table

</protect>

Notes

References

See Help:References for how to manage references in omp dev.

Retrieved from "http://bcbp-ftq4xm2.biobio.tamu.edu/omp/dev/index.php?title=PMID:16970815&oldid=6454"