Difference between revisions of "PMID:1886615"

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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
 
!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: C600
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''cysB''
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*Genotype of Experimental Strain : ''cysB'' in mutant strain SY380
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*Reference Condition:
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0000276
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increased resistance to antimicrobial compound
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Resistance to Novobiocin 
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
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*Strain: K-12
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*Substrain: AB1157
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*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''cysB''
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*Genotype of Experimental Strain : ''cysB(TS)''
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*Reference Condition:
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0000276
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increased resistance to antimicrobial compound
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Resistance to Novobiocin. Permissive temperature 30C exhibited wild type levels of resistance to Novobiocin. Temperature of 42C allowed increased resistance.
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a mutation or genetic difference within a strain
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*Taxon: Escherichia coli
 +
*Strain: K-12
 +
*Substrain: C600
 +
*NCBI Taxon ID: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=83333&lvl=3&lin=f&keep=1&srchmode=1&unlock 83333]
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*Genotype of Reference Strain: ''cysE''
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*Genotype of Experimental Strain : ''cysE'' in mutant strain SY400
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*Reference Condition:
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0000276
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increased resistance to antimicrobial compound
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Resistance to Novobiocin
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[[Category:Publication]]
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[[Category:Publication]] [[Category:Papers referenced in the LaRossa chapter]] [[Category:LaRossa citations that need review]]

Latest revision as of 18:20, 23 January 2013

Citation

Rakonjac, J, Milic, M and Savic, DJ (1991) cysB and cysE mutants of Escherichia coli K12 show increased resistance to novobiocin.Mol. Gen. Genet. 228:307-11

Abstract

Mutations in the cysB and cysE genes of Escherichia coli K12 cause an increase in resistance to the gyrase inhibitor novobiocin but not to coumermycin, acriflavine and rifampicin. This unusual relationship was also observed among spontaneous novobiocin resistant (Novr) mutants: 10% of Novr mutants isolated on rich (LA) plates with novobiocin could not grow on minimal plates, and among those approximately half were cysB or cysE mutants. Further analyses demonstrated that cysB and cysE negative alleles neither interfere with transport of novobiocin nor affect DNA supercoiling.

Links

PubMed

Keywords

Acetyltransferases; Acriflavine; Aminocoumarins; Bacterial Proteins; Cell Survival; Coumarins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Mutation; Novobiocin; Rifampin; Serine O-Acetyltransferase

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Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.
<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: C600
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: cysB
  • Genotype of Experimental Strain : cysB in mutant strain SY380
  • Reference Condition:

0000276

increased resistance to antimicrobial compound

Resistance to Novobiocin

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: AB1157
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: cysB
  • Genotype of Experimental Strain : cysB(TS)
  • Reference Condition:

0000276

increased resistance to antimicrobial compound

Resistance to Novobiocin. Permissive temperature 30C exhibited wild type levels of resistance to Novobiocin. Temperature of 42C allowed increased resistance.

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: C600
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: cysE
  • Genotype of Experimental Strain : cysE in mutant strain SY400
  • Reference Condition:

0000276

increased resistance to antimicrobial compound

Resistance to Novobiocin


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</protect>

Notes

References

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