Difference between revisions of "PMID:1916241"

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'''Cairns, J and Foster, PL'''  (1991) Adaptive reversion of a frameshift mutation in Escherichia coli. ''Genetics'' '''128''':695-701
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!align=left align='left' bgcolor='#CCCCFF' |Abstract
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Mutation rates are generally thought not to be influenced by selective forces. This doctrine rests on the results of certain classical studies of the mutations that make bacteria resistant to phages and antibiotics. We have studied a strain of Escherichia coli which constitutively expresses a lacI-lacZ fusion containing a frameshift mutation that renders it Lac-. Reversion to Lac+ is a rare event during exponential growth but occurs in stationary cultures when lactose is the only source of energy. No revertants accumulate in the absence of lactose, or in the presence of lactose if there is another, unfulfilled requirement for growth. The mechanism for such mutation in stationary phase is not known, but it requires some function of RecA which is apparently not required for mutation during exponential growth.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1916241 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204544 PMC1204544]
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!align=left align='left' bgcolor='#CCCCFF' |Keywords
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Adaptation, Biological/genetics; Adaptation, Biological/physiology; Alleles; Escherichia coli/genetics; Escherichia coli/physiology; Frameshift Mutation/genetics; Frameshift Mutation/physiology; Gene Expression Regulation, Bacterial; Genes, Bacterial/genetics; Genes, Bacterial/physiology; Genetic Variation; Lac Operon/genetics; Lac Operon/physiology; Lactose/metabolism; Lactose/pharmacology; Tryptophan/metabolism; Tryptophan/pharmacology
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==Main Points of the Paper ==
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== Materials and Methods Used ==
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==Phenotype Annotations==
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==Notes==
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==References==
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[[Category:Publication]]

Latest revision as of 16:08, 5 August 2016

Citation

Cairns, J and Foster, PL (1991) Adaptive reversion of a frameshift mutation in Escherichia coli. Genetics 128:695-701

Abstract

Mutation rates are generally thought not to be influenced by selective forces. This doctrine rests on the results of certain classical studies of the mutations that make bacteria resistant to phages and antibiotics. We have studied a strain of Escherichia coli which constitutively expresses a lacI-lacZ fusion containing a frameshift mutation that renders it Lac-. Reversion to Lac+ is a rare event during exponential growth but occurs in stationary cultures when lactose is the only source of energy. No revertants accumulate in the absence of lactose, or in the presence of lactose if there is another, unfulfilled requirement for growth. The mechanism for such mutation in stationary phase is not known, but it requires some function of RecA which is apparently not required for mutation during exponential growth.

Links

PubMed PMC1204544

Keywords

Adaptation, Biological/genetics; Adaptation, Biological/physiology; Alleles; Escherichia coli/genetics; Escherichia coli/physiology; Frameshift Mutation/genetics; Frameshift Mutation/physiology; Gene Expression Regulation, Bacterial; Genes, Bacterial/genetics; Genes, Bacterial/physiology; Genetic Variation; Lac Operon/genetics; Lac Operon/physiology; Lactose/metabolism; Lactose/pharmacology; Tryptophan/metabolism; Tryptophan/pharmacology

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Main Points of the Paper

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Materials and Methods Used

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Phenotype Annotations

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Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status
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Notes

References

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