Difference between revisions of "PMID:1886615"
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| + | {| id="U4fee372e837d4" class=" tableEdit PMID_info_table" | ||
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| + | !align=left |Citation | ||
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| + | '''Rakonjac, J, Milic, M and Savic, DJ''' (1991) cysB and cysE mutants of Escherichia coli K12 show increased resistance to novobiocin.''Mol. Gen. Genet.'' '''228''':307-11 | ||
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| + | !align=left |Abstract | ||
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| + | Mutations in the cysB and cysE genes of Escherichia coli K12 cause an increase in resistance to the gyrase inhibitor novobiocin but not to coumermycin, acriflavine and rifampicin. This unusual relationship was also observed among spontaneous novobiocin resistant (Novr) mutants: 10% of Novr mutants isolated on rich (LA) plates with novobiocin could not grow on minimal plates, and among those approximately half were cysB or cysE mutants. Further analyses demonstrated that cysB and cysE negative alleles neither interfere with transport of novobiocin nor affect DNA supercoiling. | ||
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| + | !align=left |Links | ||
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| + | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1886615 PubMed] | ||
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| + | !align=left |Keywords | ||
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| + | Acetyltransferases; Acriflavine; Aminocoumarins; Bacterial Proteins; Cell Survival; Coumarins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Mutation; Novobiocin; Rifampin; Serine O-Acetyltransferase | ||
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| + | ==Main Points of the Paper == | ||
| + | {{LitSignificance}} | ||
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| + | == Materials and Methods Used == | ||
| + | {{LitMaterials}} | ||
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| + | ==Phenotype Annotations== | ||
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| + | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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| + | ==Notes== | ||
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| + | ==References== | ||
| + | {{RefHelp}} | ||
| + | <references/> | ||
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| + | [[Category:Publication]] | ||
Revision as of 18:15, 29 June 2012
| Citation |
Rakonjac, J, Milic, M and Savic, DJ (1991) cysB and cysE mutants of Escherichia coli K12 show increased resistance to novobiocin.Mol. Gen. Genet. 228:307-11 |
|---|---|
| Abstract |
Mutations in the cysB and cysE genes of Escherichia coli K12 cause an increase in resistance to the gyrase inhibitor novobiocin but not to coumermycin, acriflavine and rifampicin. This unusual relationship was also observed among spontaneous novobiocin resistant (Novr) mutants: 10% of Novr mutants isolated on rich (LA) plates with novobiocin could not grow on minimal plates, and among those approximately half were cysB or cysE mutants. Further analyses demonstrated that cysB and cysE negative alleles neither interfere with transport of novobiocin nor affect DNA supercoiling. |
| Links | |
| Keywords |
Acetyltransferases; Acriflavine; Aminocoumarins; Bacterial Proteins; Cell Survival; Coumarins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Mutation; Novobiocin; Rifampin; Serine O-Acetyltransferase |
| edit table |
Main Points of the Paper
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Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
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</protect>
Notes
References
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