PMID:369552

Citation	Giordano, G, Grillet, L, Rosset, R, Dou, JH, Azoulay, E and Haddock, BA (1978) Characterization of an Escherichia coli K12 mutant that is sensitive to chlorate when grown aerobically.Biochem. J. 176:553-61
Abstract	Escherichia coli can normally grow aerobically in the presence of chlorate; however, mutants can be isolated that can no longer grow under these conditions. We present here the biochemical characterization of one such mutant and show that the primary genetic lesion occurs in the ubiquinone-8-biosynthetic pathway. As a consequence of this, under aerobic growth conditions the mutant is apparently unable to synthesize formate dehydrogenase, but can synthesize a Benzyl Viologen-dependent nitrate reductase activity. The nature of this activity is discussed.
Links	PubMed
Keywords	Acridines; Aerobiosis; Chlorates; Cytochromes; Escherichia coli; Formates; Mutation; NADP Transhydrogenases; Nitrate Reductases; Quinones; Spectrometry, Fluorescence
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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: 72 NCBI Taxon ID: 83333	Genotype of Reference Strain:	Reference Condition:
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