Difference between revisions of "PMID:23224554"

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'''Al Mamun, AA , Lombardo, MJ , Shee, C , Lisewski, AM , Gonzalez, C , Lin, D , Nehring, RB , Saint-Ruf, C , Gibson, JL , Frisch, RL , Lichtarge, O , Hastings, PJ  and Rosenberg, SM '''  (2012) Identity and function of a large gene network underlying mutagenic repair of DNA breaks. ''Science'' '''338''':1344-8
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!align=left  |Abstract
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Mechanisms of DNA repair and mutagenesis are defined on the basis of relatively few proteins acting on DNA, yet the identities and functions of all proteins required are unknown. Here, we identify the network that underlies mutagenic repair of DNA breaks in stressed Escherichia coli and define functions for much of it. Using a comprehensive screen, we identified a network of ≥93 genes that function in mutation. Most operate upstream of activation of three required stress responses (RpoS, RpoE, and SOS, key network hubs), apparently sensing stress. The results reveal how a network integrates mutagenic repair into the biology of the cell, show specific pathways of environmental sensing, demonstrate the centrality of stress responses, and imply that these responses are attractive as potential drug targets for blocking the evolution of pathogens.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=23224554 PubMed]
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Online version:[http://dx.doi.org/10.1126/science.1226683 10.1126/science.1226683]
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==Main Points of the Paper ==
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== Materials and Methods Used ==
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==Phenotype Annotations==
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==Notes==
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==References==
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[[Category:Publication]]

Revision as of 17:04, 13 December 2012

Citation

Al Mamun, AA , Lombardo, MJ , Shee, C , Lisewski, AM , Gonzalez, C , Lin, D , Nehring, RB , Saint-Ruf, C , Gibson, JL , Frisch, RL , Lichtarge, O , Hastings, PJ and Rosenberg, SM (2012) Identity and function of a large gene network underlying mutagenic repair of DNA breaks. Science 338:1344-8

Abstract

Mechanisms of DNA repair and mutagenesis are defined on the basis of relatively few proteins acting on DNA, yet the identities and functions of all proteins required are unknown. Here, we identify the network that underlies mutagenic repair of DNA breaks in stressed Escherichia coli and define functions for much of it. Using a comprehensive screen, we identified a network of ≥93 genes that function in mutation. Most operate upstream of activation of three required stress responses (RpoS, RpoE, and SOS, key network hubs), apparently sensing stress. The results reveal how a network integrates mutagenic repair into the biology of the cell, show specific pathways of environmental sensing, demonstrate the centrality of stress responses, and imply that these responses are attractive as potential drug targets for blocking the evolution of pathogens.

Links

PubMed Online version:10.1126/science.1226683

Keywords


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Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

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Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status
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Notes

References

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