PMID:23224554

Citation	Al Mamun, AA , Lombardo, MJ , Shee, C , Lisewski, AM , Gonzalez, C , Lin, D , Nehring, RB , Saint-Ruf, C , Gibson, JL , Frisch, RL , Lichtarge, O , Hastings, PJ and Rosenberg, SM (2012) Identity and function of a large gene network underlying mutagenic repair of DNA breaks. Science 338:1344-8
Abstract	Mechanisms of DNA repair and mutagenesis are defined on the basis of relatively few proteins acting on DNA, yet the identities and functions of all proteins required are unknown. Here, we identify the network that underlies mutagenic repair of DNA breaks in stressed Escherichia coli and define functions for much of it. Using a comprehensive screen, we identified a network of ≥93 genes that function in mutation. Most operate upstream of activation of three required stress responses (RpoS, RpoE, and SOS, key network hubs), apparently sensing stress. The results reveal how a network integrates mutagenic repair into the biology of the cell, show specific pathways of environmental sensing, demonstrate the centrality of stress responses, and imply that these responses are attractive as potential drug targets for blocking the evolution of pathogens.
Links	PubMed Online version:10.1126/science.1226683
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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: srlA Genotype of Experimental Strain : srlA777(del)::FRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ybjT Genotype of Experimental Strain : ybjT770(del)::FRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: treR Genotype of Experimental Strain : treR788(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yjcC Genotype of Experimental Strain : yjcC755(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yjcC Genotype of Experimental Strain : yjcC750::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ytjB Genotype of Experimental Strain : ytjB(P)::Tn10dCam	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: arcA Genotype of Experimental Strain : arcA(P)::Tn10dCam	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ligA Genotype of Experimental Strain : ligA(P)::Tn10dCam	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: apaG Genotype of Experimental Strain : apaG762(del)::FRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yhhK Genotype of Experimental Strain : yhhK::Tn10dCam	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ihfA Genotype of Experimental Strain : ihfA786(del)FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqgE Genotype of Experimental Strain : yqgE723(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yfjL Genotype of Experimental Strain : yfjL(P)::Tn10dCam	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: lrp Genotype of Experimental Strain : Irp787(del)::FRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: mall Genotype of Experimental Strain : mall768(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: acrA Genotype of Experimental Strain : acrA748(del)::FRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: trxB Genotype of Experimental Strain : trxB786(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: fre Genotype of Experimental Strain : fre784(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cspC Genotype of Experimental Strain : cspC747(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: barA Genotype of Experimental Strain : barA784(del)::FRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ifhA Genotype of Experimental Strain : ihfA786(del)FRTKanFRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). A strong mutation, SIM was reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiA Genotype of Experimental Strain : ubiA::Tn10dCam	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiE Genotype of Experimental Strain : ubiE778(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hfq Genotype of Experimental Strain : hfq722(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoJ Genotype of Experimental Strain : nuoJ762(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoC768 Genotype of Experimental Strain : nuoC768(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoL Genotype of Experimental Strain : nuoL760(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiH Genotype of Experimental Strain : ubiH758(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: dsbA Genotype of Experimental Strain : dsbA723(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoH Genotype of Experimental Strain : nuoH764(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yifE Genotype of Experimental Strain : yifE782(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: rppH Genotype of Experimental Strain : rppH754(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: rpoE Genotype of Experimental Strain : rpoE2072::Tn10dCam	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: prc Genotype of Experimental Strain : prc755(del)::FRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: lon Genotype of Experimental Strain : lon725(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nagC Genotype of Experimental Strain : nagC725(del)::FRTKanFRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoG Genotype of Experimental Strain : nuoG::Tn10dCam	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: rbsK Genotype of Experimental Strain : rbsK781(del)::FRTKanFRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pepP Genotype of Experimental Strain : pepP759(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hemL Genotype of Experimental Strain : hemL::Tn10dCam	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pepP Genotype of Experimental Strain : pepP759(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pstB Genotype of Experimental Strain : pstB756(del)::FRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiX Genotype of Experimental Strain : ubiX732(del)::FRTKanFRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hdfR Genotype of Experimental Strain : hdfR785(del)::FRT	Reference Condition:					A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: zncC Genotype of Experimental Strain : znuC783(del)::FRT	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoK Genotype of Experimental Strain : nuoK761(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgi Genotype of Experimental Strain : pgi721(del)FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ygfA Genotype of Experimental Strain : ygfA763(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yigP Genotype of Experimental Strain : yigP::Tn10dCam	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: mdh761 Genotype of Experimental Strain : mdh761(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyaA751 Genotype of Experimental Strain : cyaA751(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: tatC781 Genotype of Experimental Strain : tatC781(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: glnK736 Genotype of Experimental Strain : glnK736(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: sdhB774 Genotype of Experimental Strain : sdhB774(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqiC737 Genotype of Experimental Strain : yqiC737(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: apaH761 Genotype of Experimental Strain : apaH761(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoA789 Genotype of Experimental Strain : cyoA789(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hscB773 Genotype of Experimental Strain : hscB773(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoD786 Genotype of Experimental Strain : cyoD786(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: dsbC744 Genotype of Experimental Strain : dsbC744(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pstC Genotype of Experimental Strain : pstC758(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: znuA782 Genotype of Experimental Strain : znuA782(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgl739 Genotype of Experimental Strain : pgl739(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: argR762 Genotype of Experimental Strain : argR762(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: fru+ Genotype of Experimental Strain : fruR786(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: speE+ Genotype of Experimental Strain : speE739(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: sdhD+ Genotype of Experimental Strain : sdhD772(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cysD+ Genotype of Experimental Strain : cysD(P)::Tn10dCam	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: speD+ Genotype of Experimental Strain : speD738(del)::FRTKanFRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: proL Genotype of Experimental Strain : proL::Tn10dCam	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: lipB Genotype of Experimental Strain : lipB769(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: znuA782 Genotype of Experimental Strain : znuA782(del)::FRT	Reference Condition:					Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiD Genotype of Experimental Strain : ubiD::Tn10dCam	Reference Condition:					Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
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References

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