Difference between revisions of "PMID:21541325"
(Table edited by JimHu via TableEdit) |
(Table edited by Siegele via TableEdit) |
||
| Line 48: | Line 48: | ||
* | * | ||
****************************************************************************************** --> | ****************************************************************************************** --> | ||
| − | {| | + | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="F4eee9e407d8ed" class=" tableEdit Phenotype_Table_2" |
| − | |- | + | |- align='left' bgcolor='#CCCCFF' |
!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
|- | |- | ||
| Line 65: | Line 65: | ||
*Reference Condition: | *Reference Condition: | ||
| | | | ||
| − | + | OMP:0005077 | |
| | | | ||
| − | + | decreased resistance to acidic pH stres | |
| | | | ||
| Line 80: | Line 80: | ||
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=2ccfb3c7bf1208312f02a69e64bfd9e0.2823.F4eee9e407d8ed&page=2823&pagename={{FULLPAGENAMEE}}&type=0&template=Phenotype_Table_2 edit table]</span> || || || || || || || || || | |<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=2ccfb3c7bf1208312f02a69e64bfd9e0.2823.F4eee9e407d8ed&page=2823&pagename={{FULLPAGENAMEE}}&type=0&template=Phenotype_Table_2 edit table]</span> || || || || || || || || || | ||
|} | |} | ||
| + | <noinclude> | ||
| + | |||
| + | </noinclude> | ||
<!--box uid=2ccfb3c7bf1208312f02a69e64bfd9e0.2823.F4eee9e407d8ed--></protect> | <!--box uid=2ccfb3c7bf1208312f02a69e64bfd9e0.2823.F4eee9e407d8ed--></protect> | ||
Revision as of 17:06, 15 January 2015
| Citation |
Deininger, KN, Horikawa, A, Kitko, RD, Tatsumi, R, Rosner, JL, Wachi, M and Slonczewski, JL (2011) A requirement of TolC and MDR efflux pumps for acid adaptation and GadAB induction in Escherichia coli.PLoS ONE 6:e18960 |
|---|---|
| Abstract |
The TolC outer membrane channel is a key component of several multidrug resistance (MDR) efflux pumps driven by H(+) transport in Escherichia coli. While tolC expression is under the regulation of the EvgA-Gad acid resistance regulon, the role of TolC in growth at low pH and extreme-acid survival is unknown. |
| Links |
PubMed Online version:10.1371/journal.pone.0018960 |
| Keywords |
Acids; Adaptation, Physiological; Bacterial Outer Membrane Proteins; Drug Resistance, Multiple; Enzyme Induction; Escherichia coli K12; Escherichia coli Proteins; Glutamate Decarboxylase; Glutamates; Hydrogen-Ion Concentration; Membrane Proteins; Membrane Transport Proteins; Microbial Viability; Mutation |
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
See Help:AnnotationTable for details on how to edit this table.
<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
|
a mutation or genetic difference within a strain |
|
|
|
OMP:0005077 |
decreased resistance to acidic pH stres |
TolC was required for EXTREME-acid survival (pH 2) of strain W3110 grown aerobically to stationary phase. A tolC deletion decreased extreme-acid survival (acid resistance) of aerated pH 7.0-grown cells by 105-fold and of pH 5.5-grown cells by 10-fold. TolC was required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad). TolC was also required for maximal exponential growth of E. coli K-12 W3110, in LBK medium buffered at pH 4.5-6.0, but not at pH 6.5-8.5. The TolC growth requirement in moderate acid was independent of Gad. |
| ||
| edit table |
</protect>
Notes
References
See Help:References for how to manage references in omp dev.
