Difference between revisions of "PMID:333433"

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'''Springer, MS, Goy, MF and Adler, J'''  (1977) Sensory transduction in Escherichia coli: two complementary pathways of information processing that involve methylated proteins. ''Proc. Natl. Acad. Sci. U.S.A.'' '''74''':3312-6
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!align=left align='left' bgcolor='#CCCCFF' |Abstract
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The properties of two classes of behavioral mutants of Escherichia coli (called tsr and tar) are described. The mutations in these strains define two complementary pathways of information flow in bacterial chemotaxis: behavioral responses to one set of stimuli are defective in tsr mutants, while responses to a complementary set of stimuli are defective in tar mutants. A double mutant containing both genetic lesions is defective in responses to all stimuli tested. The behavioral defects are shown to correlate with alterations in the properties of a methylation reaction involved in chemotaxis. Two independent sets of methyl-accepting proteins are demonstrated in the wild type, each set functioning in one of the two pathways mentioned above. Methylation of one set of proteins is defective in tsr mutants, while methylation of the complementary set is defective in tar mutants. The double mutant shows no methylation of either set. The relationship between the genetic loci (tsr and tar) and the methyl-accepting proteins is discussed.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=333433 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC431543 PMC431543]
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!align=left align='left' bgcolor='#CCCCFF' |Keywords
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Bacterial Proteins/biosynthesis; Chemotaxis; Escherichia coli/genetics; Escherichia coli/metabolism; Genes; Methylation; Molecular Weight; Mutation; Species Specificity; Transduction, Genetic
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==Main Points of the Paper ==
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== Materials and Methods Used ==
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==Phenotype Annotations==
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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==Notes==
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==References==
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[[Category:Publication]]

Latest revision as of 12:53, 23 June 2015

Citation

Springer, MS, Goy, MF and Adler, J (1977) Sensory transduction in Escherichia coli: two complementary pathways of information processing that involve methylated proteins. Proc. Natl. Acad. Sci. U.S.A. 74:3312-6

Abstract

The properties of two classes of behavioral mutants of Escherichia coli (called tsr and tar) are described. The mutations in these strains define two complementary pathways of information flow in bacterial chemotaxis: behavioral responses to one set of stimuli are defective in tsr mutants, while responses to a complementary set of stimuli are defective in tar mutants. A double mutant containing both genetic lesions is defective in responses to all stimuli tested. The behavioral defects are shown to correlate with alterations in the properties of a methylation reaction involved in chemotaxis. Two independent sets of methyl-accepting proteins are demonstrated in the wild type, each set functioning in one of the two pathways mentioned above. Methylation of one set of proteins is defective in tsr mutants, while methylation of the complementary set is defective in tar mutants. The double mutant shows no methylation of either set. The relationship between the genetic loci (tsr and tar) and the methyl-accepting proteins is discussed.

Links

PubMed PMC431543

Keywords

Bacterial Proteins/biosynthesis; Chemotaxis; Escherichia coli/genetics; Escherichia coli/metabolism; Genes; Methylation; Molecular Weight; Mutation; Species Specificity; Transduction, Genetic



Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

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<protect>

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status


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Notes

References

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