Difference between revisions of "PMID:4604054"
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| + | !align=left align='left' bgcolor='#CCCCFF' |Citation | ||
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| + | '''Ackerman, RS, Cozzarelli, NR and Epstein, W''' (1974) Accumulation of toxic concentrations of methylglyoxal by wild-type Escherichia coli K-12. ''J. Bacteriol.'' '''119''':357-62 | ||
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| + | !align=left align='left' bgcolor='#CCCCFF' |Abstract | ||
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| + | Wild-type strains of Escherichia coli K-12 accumulate toxic concentrations of methylglyoxal when grown in medium containing adenosine 3',5'-monophosphate and either d-xylose, l-arabinose, or d-glucose-6-phosphate, independent of the presence of other carbon sources. Mutations at a locus called cxm specifically block methylglyoxal formation from xylose in the presence of adenosine 3',5'-monophosphate. Accumulation in medium containing xylose, studied in some detail, is dependent on the ability to utilize xylose and is associated with an increased rate of xylose utilization without changes in levels of xylose isomerase. These results suggest that adenosine 3',5'-monophosphate results in induction of excessively high levels of an early rate-limiting step in xylose metabolism. This step may be the transport of xylose into the cell. The resulting excessive rates of xylose catabolism could stimulate methylglyoxal formation by overburdening late steps in glycolysis. | ||
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| + | !align=left align='left' bgcolor='#CCCCFF' |Links | ||
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| + | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4604054 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC245615 PMC245615] | ||
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| + | !align=left align='left' bgcolor='#CCCCFF' |Keywords | ||
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| + | Adenosine Monophosphate/metabolism; Aldehydes/biosynthesis; Aldehydes/pharmacology; Carbohydrate Epimerases/metabolism; Carbon Radioisotopes; Cell-Free System; Chromatography, Paper; Culture Media; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/metabolism; Mutation; Xylose/metabolism | ||
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| + | ==Main Points of the Paper == | ||
| + | {{LitSignificance}} | ||
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| + | == Materials and Methods Used == | ||
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| + | ==Phenotype Annotations== | ||
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| + | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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| + | ==Notes== | ||
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| + | ==References== | ||
| + | {{RefHelp}} | ||
| + | <references/> | ||
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| + | [[Category:Publication]] | ||
Latest revision as of 13:52, 10 July 2015
| Citation |
Ackerman, RS, Cozzarelli, NR and Epstein, W (1974) Accumulation of toxic concentrations of methylglyoxal by wild-type Escherichia coli K-12. J. Bacteriol. 119:357-62 |
|---|---|
| Abstract |
Wild-type strains of Escherichia coli K-12 accumulate toxic concentrations of methylglyoxal when grown in medium containing adenosine 3',5'-monophosphate and either d-xylose, l-arabinose, or d-glucose-6-phosphate, independent of the presence of other carbon sources. Mutations at a locus called cxm specifically block methylglyoxal formation from xylose in the presence of adenosine 3',5'-monophosphate. Accumulation in medium containing xylose, studied in some detail, is dependent on the ability to utilize xylose and is associated with an increased rate of xylose utilization without changes in levels of xylose isomerase. These results suggest that adenosine 3',5'-monophosphate results in induction of excessively high levels of an early rate-limiting step in xylose metabolism. This step may be the transport of xylose into the cell. The resulting excessive rates of xylose catabolism could stimulate methylglyoxal formation by overburdening late steps in glycolysis. |
| Links | |
| Keywords |
Adenosine Monophosphate/metabolism; Aldehydes/biosynthesis; Aldehydes/pharmacology; Carbohydrate Epimerases/metabolism; Carbon Radioisotopes; Cell-Free System; Chromatography, Paper; Culture Media; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/metabolism; Mutation; Xylose/metabolism |
| edit table |
Main Points of the Paper
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Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
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<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
| edit table |
</protect>
Notes
References
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