Difference between revisions of "PMID:372756"
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| + | {| id="V4f7f5e4fb76d5" class=" tableEdit PMID_info_table" | ||
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| + | !align=left |Citation | ||
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| + | '''Hummel, H, Piepersberg, W and Böck, A''' (1979) Analysis of lincomycin resistance mutations in Escherichia coli.''Mol. Gen. Genet.'' '''169''':345-7 | ||
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| + | !align=left |Abstract | ||
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| + | High level lincomycin resistant strains of Escherichia coli were isolated and screened for altered ribosomal proteins and functions. Amongst 58 strains investigated by electrophoresis one had an altered ribosomal protein S7, another one a mutated L14 and two showed altered L15 proteins. A correlation between these alterations and lincomycin resistant growth could not be demonstrated by genetic analysis for any of the mutants. In vitro, however, extracts from the two L15 mutants were less sensitive to inhibition by the drug. A gene locus (linR) responsible for the lincomycin resistance phenotype was mapped at min 30 of the Escherichia coli chromosome near tyrR; it seems to be identical to the previously described linB locus (Apirion, 1967); however, in contrast to these reports it does not seem to alter any ribosomal function. | ||
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| + | !align=left |Links | ||
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| + | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=372756 PubMed] | ||
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| + | !align=left |Keywords | ||
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| + | Bacterial Proteins; Drug Resistance, Microbial; Electrophoresis; Escherichia coli; Lincomycin; Mutation; Phenotype; Ribosomal Proteins | ||
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| + | ==Main Points of the Paper == | ||
| + | {{LitSignificance}} | ||
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| + | == Materials and Methods Used == | ||
| + | {{LitMaterials}} | ||
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| + | ==Phenotype Annotations== | ||
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| + | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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| + | ==Notes== | ||
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| + | ==References== | ||
| + | {{RefHelp}} | ||
| + | <references/> | ||
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| + | [[Category:Publication]] | ||
Revision as of 16:21, 6 April 2012
| Citation |
Hummel, H, Piepersberg, W and Böck, A (1979) Analysis of lincomycin resistance mutations in Escherichia coli.Mol. Gen. Genet. 169:345-7 |
|---|---|
| Abstract |
High level lincomycin resistant strains of Escherichia coli were isolated and screened for altered ribosomal proteins and functions. Amongst 58 strains investigated by electrophoresis one had an altered ribosomal protein S7, another one a mutated L14 and two showed altered L15 proteins. A correlation between these alterations and lincomycin resistant growth could not be demonstrated by genetic analysis for any of the mutants. In vitro, however, extracts from the two L15 mutants were less sensitive to inhibition by the drug. A gene locus (linR) responsible for the lincomycin resistance phenotype was mapped at min 30 of the Escherichia coli chromosome near tyrR; it seems to be identical to the previously described linB locus (Apirion, 1967); however, in contrast to these reports it does not seem to alter any ribosomal function. |
| Links | |
| Keywords |
Bacterial Proteins; Drug Resistance, Microbial; Electrophoresis; Escherichia coli; Lincomycin; Mutation; Phenotype; Ribosomal Proteins |
| edit table |
Main Points of the Paper
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Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
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<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
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</protect>
Notes
References
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