PMID:372756

Citation	Hummel, H, Piepersberg, W and Böck, A (1979) Analysis of lincomycin resistance mutations in Escherichia coli.Mol. Gen. Genet. 169:345-7
Abstract	High level lincomycin resistant strains of Escherichia coli were isolated and screened for altered ribosomal proteins and functions. Amongst 58 strains investigated by electrophoresis one had an altered ribosomal protein S7, another one a mutated L14 and two showed altered L15 proteins. A correlation between these alterations and lincomycin resistant growth could not be demonstrated by genetic analysis for any of the mutants. In vitro, however, extracts from the two L15 mutants were less sensitive to inhibition by the drug. A gene locus (linR) responsible for the lincomycin resistance phenotype was mapped at min 30 of the Escherichia coli chromosome near tyrR; it seems to be identical to the previously described linB locus (Apirion, 1967); however, in contrast to these reports it does not seem to alter any ribosomal function.
Links	PubMed
Keywords	Bacterial Proteins; Drug Resistance, Microbial; Electrophoresis; Escherichia coli; Lincomycin; Mutation; Phenotype; Ribosomal Proteins
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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: TS14-13-10 NCBI Taxon ID: 83333	Genotype of Reference Strain: rpsS Genotype of Experimental Strain : rpsS	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	Three step tiamulin resistance, table 1 and 2
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: TS15-23 NCBI Taxon ID: 83333	Genotype of Reference Strain: rplD Genotype of Experimental Strain : rplD	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	Two step Tiamulin resistant, table 1 and 2
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: TS10-21 NCBI Taxon ID: 83333	Genotype of Reference Strain: rplC Genotype of Experimental Strain : rplC	Reference Condition:	OMP:0000276	increased resistance to antibiotics	ECO:0000182	in vitro culture assay data	rplC(L3) two step tiamulin resistant in strain 1 and 2
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References

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