PMID:6355059

Citation	Stalmach, ME, Grothe, S and Wood, JM (1983) Two proline porters in Escherichia coli K-12.J. Bacteriol. 156:481-6
Abstract	Escherichia coli mutants defective at putP and putA lack proline transport via proline porter I and proline dehydrogenase activity, respectively. They retain a proline uptake system (proline porter II) that is induced during tryptophan-limited growth and are sensitive to the toxic L-proline analog, 3,4-dehydroproline. 3,4-Dehydroproline-resistant mutants derived from a putP putA mutant lack proline porter II. Auxotrophic derivatives derived from putP+ or putP bacteria can grow if provided with proline at low concentration (25 microM); those derived from the 3,4-dehydroproline-resistant mutants require high proline for growth (2.5 mM). We conclude that E. coli, like Salmonella typhimurium, possesses a second proline porter that is inactivated by mutations at the proP locus.
Links	PubMed
Keywords	Amino Acid Transport Systems, Neutral; Escherichia coli; Genes, Bacterial; Genotype; Isoenzymes; Kinetics; Membrane Transport Proteins; Mutation; Proline; Species Specificity
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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
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