Difference between revisions of "PMID:1886615"
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Revision as of 18:16, 29 June 2012
| Citation |
Rakonjac, J, Milic, M and Savic, DJ (1991) cysB and cysE mutants of Escherichia coli K12 show increased resistance to novobiocin.Mol. Gen. Genet. 228:307-11 |
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| Abstract |
Mutations in the cysB and cysE genes of Escherichia coli K12 cause an increase in resistance to the gyrase inhibitor novobiocin but not to coumermycin, acriflavine and rifampicin. This unusual relationship was also observed among spontaneous novobiocin resistant (Novr) mutants: 10% of Novr mutants isolated on rich (LA) plates with novobiocin could not grow on minimal plates, and among those approximately half were cysB or cysE mutants. Further analyses demonstrated that cysB and cysE negative alleles neither interfere with transport of novobiocin nor affect DNA supercoiling. |
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| Keywords |
Acetyltransferases; Acriflavine; Aminocoumarins; Bacterial Proteins; Cell Survival; Coumarins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Mutation; Novobiocin; Rifampin; Serine O-Acetyltransferase |
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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References
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