Difference between revisions of "PMID:350837"
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| + | {| id="T509c03d881c09" class=" tableEdit PMID_info_table" | ||
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| + | !align=left |Citation | ||
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| + | '''Duncan, BK , Rockstroh, PA and Warner, HR ''' (1978) Escherichia coli K-12 mutants deficient in uracil-DNA glycosylase. ''J. Bacteriol.'' '''134''':1039-45 | ||
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| + | !align=left |Abstract | ||
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| + | A new assay specific for uracil-DNA glycosylase is described, Escherichia coli mutants partially and totally deficient in uracil-DNA glycosylase activity have been isolated by using this assay in mass-screening procedures. These have been designated ung mutants. The ung gene maps between tyrA and nadB on the E. coli chromosome. T4 phage containing uracil in their DNA grow on the most glycosylase-deficient hosts but are unable to grow on wild-type bacteria. This provides a simple spot test for the ung genotype. The ung mutants show slightly higher rates of spontaneous mutation to antibiotic resistance. Taken together, these results suggest a central role for uracil-DNA glycosylase in the initiation of an excision repair pathway for the exclusion of uracil from DNA. | ||
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| + | !align=left |Links | ||
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| + | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=350837 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC222353 PMC222353] | ||
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| + | !align=left |Keywords | ||
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| + | Chromosome Mapping; Coliphages/analysis; Coliphages/growth & development; DNA Repair; DNA, Viral/analysis; Deoxyuracil Nucleotides; Escherichia coli/genetics; Genes; Mutation; N-Glycosyl Hydrolases/genetics; Uracil/analysis | ||
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| + | ==Main Points of the Paper == | ||
| + | {{LitSignificance}} | ||
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| + | == Materials and Methods Used == | ||
| + | {{LitMaterials}} | ||
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| + | ==Phenotype Annotations== | ||
| + | {{AnnotationTableHelp}} | ||
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| + | {| id="P509c03d8c777c" class=" tableEdit Phenotype_Table_2" | ||
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| + | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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| + | ==Notes== | ||
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| + | ==References== | ||
| + | {{RefHelp}} | ||
| + | <references/> | ||
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| + | [[Category:Publication]] | ||
Revision as of 14:11, 8 November 2012
| Citation |
Duncan, BK , Rockstroh, PA and Warner, HR (1978) Escherichia coli K-12 mutants deficient in uracil-DNA glycosylase. J. Bacteriol. 134:1039-45 |
|---|---|
| Abstract |
A new assay specific for uracil-DNA glycosylase is described, Escherichia coli mutants partially and totally deficient in uracil-DNA glycosylase activity have been isolated by using this assay in mass-screening procedures. These have been designated ung mutants. The ung gene maps between tyrA and nadB on the E. coli chromosome. T4 phage containing uracil in their DNA grow on the most glycosylase-deficient hosts but are unable to grow on wild-type bacteria. This provides a simple spot test for the ung genotype. The ung mutants show slightly higher rates of spontaneous mutation to antibiotic resistance. Taken together, these results suggest a central role for uracil-DNA glycosylase in the initiation of an excision repair pathway for the exclusion of uracil from DNA. |
| Links | |
| Keywords |
Chromosome Mapping; Coliphages/analysis; Coliphages/growth & development; DNA Repair; DNA, Viral/analysis; Deoxyuracil Nucleotides; Escherichia coli/genetics; Genes; Mutation; N-Glycosyl Hydrolases/genetics; Uracil/analysis |
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
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<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
| edit table |
</protect>
Notes
References
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