PMID:23697806
| Citation |
Hayles, J, Wood, V, Jeffery, L, Hoe, KL, Kim, DU, Park, HO, Salas-Pino, S, Heichinger, C and Nurse, P (2013) A genome-wide resource of cell cycle and cell shape genes of fission yeast. Open Biol 3:130053 |
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| Abstract |
To identify near complete sets of genes required for the cell cycle and cell shape, we have visually screened a genome-wide gene deletion library of 4843 fission yeast deletion mutants (95.7% of total protein encoding genes) for their effects on these processes. A total of 513 genes have been identified as being required for cell cycle progression, 276 of which have not been previously described as cell cycle genes. Deletions of a further 333 genes lead to specific alterations in cell shape and another 524 genes result in generally misshapen cells. Here, we provide the first eukaryotic resource of gene deletions, which describes a near genome-wide set of genes required for the cell cycle and cell shape. |
| Links |
PubMed PMC3866870 Online version:10.1098/rsob.130053 |
| Keywords |
Cell Cycle/genetics; Computational Biology; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Fungal; Genes, cdc; Genome, Fungal; Humans; Mutagenesis; Phenotype; Schizosaccharomyces/cytology; Schizosaccharomyces/genetics; Schizosaccharomyces pombe Proteins/genetics |
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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