PMID:15687217
| Citation |
Pérez-Capilla, T, Baquero, MR, Gómez-Gómez, JM, Ionel, A, Martín, S and Blázquez, J (2005) SOS-independent induction of dinB transcription by beta-lactam-mediated inhibition of cell wall synthesis in Escherichia coli. J. Bacteriol. 187:1515-8 |
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| Abstract |
Transcription of the dinB gene, encoding DNA polymerase IV, is induced by the inhibition of cell wall synthesis at different levels. Using the beta-lactam antibiotic ceftazidime, a PBP3 inhibitor, as a model, we have shown that this induction is independent of the LexA/RecA regulatory system. Induction of dinB transcription mediated by ceftazidime produces an increase in the reversion of a +1 Lac frameshift mutation. |
| Links |
PubMed PMC545630 Online version:10.1128/JB.187.4.1515-1518.2005 |
| Keywords |
Adenosine Triphosphatases/physiology; Bacterial Proteins/physiology; Ceftazidime/pharmacology; Cell Wall/metabolism; DNA Helicases/physiology; Enzyme Inhibitors/pharmacology; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Frameshift Mutation; Gene Expression Regulation, Bacterial/drug effects; SOS Response (Genetics); Serine Endopeptidases/physiology; Transcription, Genetic; beta-Galactosidase/analysis; beta-Galactosidase/genetics |
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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