PMID:4934063
| Citation |
Im, SW and Pittard, J (1971) Phenylalanine biosynthesis in Escherichia coli K-12: mutants derepressed for chorismate mutase P-prephenate dehydratase.J. Bacteriol. 106:784-90 |
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| Abstract |
Mutants were isolated which are derepressed for the synthesis of chorismate mutase P-prephenate dehydratase. No other enzymes involved in the synthesis of phenylalanine are derepressed in these strains. These mutants are able to grow in concentrations of o- and p-fluorophenylalanine that inhibit the growth of AB3259, the strain from which they were derived. They also excrete phenylalanine. Genetic analysis shows that the mutations causing this derepression are closely linked to the structural gene for this enzyme (cotransduction frequency of 95% or more with pheA). The gene in which they occur has been designated pheO since this gene has all of the properties predicted for an operator gene controlling the pheA structural gene. Finally, the pheO mutant alleles have been shown to be dominant in diploids. |
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| Keywords |
Chromatography, DEAE-Cellulose; Culture Media; Escherichia coli; Genes; Genetics, Microbial; Hydro-Lyases; Mutagens; Mutation; Phenylalanine; Phosphotransferases; Transduction, Genetic |
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Main Points of the Paper
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Materials and Methods Used
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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Resistant to Fluoro(4)phenylalanine resistance |
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Notes
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