PMID:6760806

Citation	Jaffe, A, Chabbert, YA and Semonin, O (1982) Role of porin proteins OmpF and OmpC in the permeation of beta-lactams.Antimicrob. Agents Chemother. 22:942-8
Abstract	Mutants of Escherichia coli K-12 lacking major outer membrane proteins were obtained by selecting for resistance to the beta-lactam cefoxitin. Three classes of resistant strains were found: mutants in ompB, a regulatory locus for proteins OmpF and OmpC; mutants in ompF; and one mutant in tpo. The OmpF and OmpC proteins facilitate penetration of beta-lactams through the outer membrane.
Links	PubMed
Keywords	Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; Carrier Proteins; Cell Membrane Permeability; Escherichia coli; Hexosyltransferases; Membrane Proteins; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases; beta-Lactams
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Main Points of the Paper

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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: B1466 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF1466	Reference Condition:	OMP:0000276	increased resistance to antimicrobial compound			Resistance to beta lactam ampicillin
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: B1466 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompF Genotype of Experimental Strain : ompF1466	Reference Condition:	OMP:0000276	increased resistance to antimicrobial compound			Resistance to beta lactam Cefoxitin
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: B1436 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompB Genotype of Experimental Strain : ompB1422	Reference Condition:	OMP:0000276	increased resistance to antimicrobial compound			Resistance to beta lactam Cefoxitin
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: B1436 NCBI Taxon ID: 83333	Genotype of Reference Strain: ompB Genotype of Experimental Strain : ompB1422	Reference Condition:	OMP:0000276	increased resistance to antimicrobial compound			Resistance to beta lactam ampicillin
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Notes

ECO: The term Solid medium (in vivo) is awaiting approval to add.

OMP:

References

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