PMID:6264273
| Citation |
Ostrowski, J and Hulanicka, D (1981) Effect of DNA gyrase inhibitors on gene expression of the cysteine regulon.Mol. Gen. Genet. 181:363-6 |
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| Abstract |
Nalidixic acid inhibits the expression of those cysteine genes which are regulated by the cysB product, it has no affect, however, on the constitutively-expressed cysE gene. The expression of cysteine genes in a strain carrying a mutation in the nalA locus is resistant to this drug. Novobiocin affects the expression of cysteine genes similarly to nalidixic acid. The effect of nalidixic acid on the expression of genes in a cysteine constitutive mutant was studied. |
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| Keywords |
Acetyltransferases; Cysteine; Cysteine Synthase; Gene Expression Regulation; Genes, Regulator; Mutation; Nalidixic Acid; Novobiocin; Oxidoreductases Acting on Sulfur Group Donors; Salmonella typhimurium; Serine O-Acetyltransferase; Topoisomerase II Inhibitors |
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Main Points of the Paper
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Materials and Methods Used
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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OMP:0000276 |
increased resistance to antimicrobial compound |
Resistant to antibiotic nalidixic acid. |
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