id: ECO:0000088
name: biological system reconstruction
def: "Evidence based on reconstruction of a biological system that is based on an existing experimentally supported model of that biological system." [ECO:MCC, GOC:mg]
synonym: "inferred from system reconstruction" RELATED []
synonym: "ISR" RELATED []
is_a: ECO:0000000 ! evidence
comment: The biological system in question might be a multi-step process or a physical complex comprising several components. A common basis for system reconstruction is orthology, where all of the components of an experimentally characterized complex exist in one organism; if a second organism contains orthologs of all components, then the existence of the complex is inferred. In the case of a genome-wide analysis, a gene product is said to fulfill a necessary function for a pathway or complex when, with all of the other necessary functions or components also present, the pathway or complex is reconstructed.
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