Category:ECO:0001827 ! methylation interference footprinting evidence

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id: ECO:0001827

name: methylation interference footprinting evidence
def: "A type of nucleic acid binding evidence used to identify protein binding sites on the DNA molecule where multiple copies of a DNA fragment containing a putative TF-binding site are randomly methylated with dimethyl sulfate (DMS) and cleaved at the methyl group, followed by separating the cleavage products on a denaturing electrophoresis gel." [ECO:SW, PMID:1583685]
synonym: "methylation interference footprinting evidence" EXACT []
is_a: ECO:0000136 ! nucleic acid binding evidence

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