PMID:10564486
| Citation |
Carballès, F, Bertrand, C, Bouché, JP and Cam, K (1999) Regulation of Escherichia coli cell division genes ftsA and ftsZ by the two-component system rcsC-rcsB.Mol. Microbiol. 34:442-50 |
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| Abstract |
Genes rcsC and rcsB form a two-component system in which rcsC encodes the sensor element and rcsB the regulator. In Escherichia coli, the system positively regulates the expression of the capsule operon, cps, and of the cell division gene ftsZ. We report the identification of the promoter and of the sequences required for rcsB-dependent stimulation of ftsZ expression. The promoter, ftsA1p, located in the ftsQ coding sequence, co-regulates ftsA and ftsZ. The sequences required for rcsB activity are immediately adjacent to this promoter. |
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| Keywords |
Bacterial Proteins; Base Sequence; Cell Division; Cytoskeletal Proteins; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Gene Expression Regulation, Bacterial; Genes, Bacterial; Molecular Sequence Data; Multienzyme Complexes; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Protein Kinases; Transcription Factors; Transcription, Genetic |
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Main Points of the Paper
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Materials and Methods Used
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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ECO:0007118 |
decreased transcription |
ECO:0000016 |
loss-of-function mutant phenotype evidence |
Sequences needed for RcsB activation of ftsA1p were defined by deletion (Fig. 1) and point mutations (Fig. 3). |
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Notes
References
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