PMID:12761067
| Citation |
Gagneur, J , Jackson, DB and Casari, G (2003) Hierarchical analysis of dependency in metabolic networks. Bioinformatics 19:1027-34 |
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| Abstract |
Elucidation of metabolic networks for an increasing number of organisms reveals that even small networks can contain thousands of reactions and chemical species. The intimate connectivity between components complicates their decomposition into biologically meaningful sub-networks. Moreover, traditional higher-order representations of metabolic networks as metabolic pathways, suffers from the lack of rigorous definition, yielding pathways of disparate content and size. |
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| Keywords |
Algorithms; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression Regulation, Bacterial/physiology; Metabolism/genetics; Metabolism/physiology; Models, Biological; Models, Statistical; Multienzyme Complexes/physiology; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic; Stochastic Processes |
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