PMID:1551857
| Citation |
Beall, B and Lutkenhaus, J (1992) Impaired cell division and sporulation of a Bacillus subtilis strain with the ftsA gene deleted. J. Bacteriol. 174:2398-403 |
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| Abstract |
The ftsZ and ftsA genes of Bacillus subtilis are organized in a simple operon expressed from promoter sequences immediately upstream of ftsA. The promoter-distal ftsZ gene is an essential septation gene. In this report, it is shown that the promoter-proximal ftsA gene can be deleted in a previously constructed strain in which the essential gene, ftsZ, is under the control of the inducible spac promoter. Absence of the ftsA gene product resulted in a very filamentous morphology indicating an important role for ftsA in cell division. Also, growth was severely impaired, and viability and sporulation were reduced. The defective sporulation phenotype correlated with a deficiency in the processing of pro-sigma E to its active form. |
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| Keywords |
Bacillus subtilis/cytology; Bacillus subtilis/genetics; Cell Division; Chromosome Deletion; DNA Mutational Analysis; DNA, Bacterial/genetics; Genes, Bacterial; Restriction Mapping; Spores, Bacterial |
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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