PMID:1625583
| Citation |
Rakonjac, J, Milic, M, Ajdic-Predic, D, Santos, D, Ivanisevic, R and Savic, DJ (1992) nov: a new genetic locus that affects the response of Escherichia coli K-12 to novobiocin.Mol. Microbiol. 6:1547-53 |
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| Abstract |
We have identified a new gene locus (nov) affecting the resistance of Escherichia coli K-12 to novobiocin. The gene also affects, although to a lesser extent, tolerance to another gyrase inhibitor coumermycin. Transductional and complementation analysis show that nov is located between att phi 80 and the osmZ (hns) genes at minute 27 of the E. coli K-12 genetic map. In standard laboratory strains of E. coli K-12 nov exists at least in two allelic forms. |
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| Keywords |
Alleles; Aminocoumarins; Biological Transport; Cell Membrane Permeability; Chromosome Mapping; Coumarins; DNA, Bacterial; DNA, Superhelical; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Genes, Suppressor; Mutation; Novobiocin |
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Main Points of the Paper
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Materials and Methods Used
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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OMP:0000276 |
increased resistance to antibiotics |
ECO:0000182 |
in vitro culture assay data |
Resistance to Novobiocin, table 2 |
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Notes
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