PMID:16452433

Citation	Wang, SC , West, L and Shapiro, L (2006) The bifunctional FtsK protein mediates chromosome partitioning and cell division in Caulobacter. J. Bacteriol. 188:1497-508
Abstract	Bacterial chromosome partitioning and cell division are tightly connected cellular processes. We show here that the Caulobacter crescentus FtsK protein localizes to the division plane, where it mediates multiple functions involved in chromosome segregation and cytokinesis. The first 258 amino acids of the N terminus are necessary and sufficient for targeting the protein to the division plane. Furthermore, the FtsK N terminus is required to either assemble or maintain FtsZ rings at the division plane. The FtsK C terminus is essential in Caulobacter and is involved in maintaining accurate chromosome partitioning. In addition, the C-terminal region of FtsK is required for the localization of the topoisomerase IV ParC subunit to the replisome to facilitate chromosomal decatenation prior to cell division. These results suggest that the interdependence between chromosome partitioning and cell division in Caulobacter is mediated, in part, by the FtsK protein.
Links	PubMed PMC1367234 Online version:10.1128/JB.188.4.1497-1508.2006
Keywords	Bacterial Proteins/physiology; Caulobacter crescentus/genetics; Caulobacter crescentus/physiology; Cell Division; Chromosome Segregation; Chromosomes, Bacterial/physiology; DNA Topoisomerase IV/metabolism
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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
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