PMID:165645

Citation	Myllylä, VV, Heikkinen, ER, Similä, S, Hokkanen, E and Vapaatalo, H (1975) Cerebrospinal fluid concentration and urinary excretion of cyclic adenosine-3', 5'-monophosphate in various diseases of children.Z Kinderheilkd 118:259-64
Abstract	Cerebrospinal fluid (CSF) concentration and urinary excretion of cyclic adenosine-3',5'-monophosphate(cAMP) were measured in children aged from 3 days to 15 years by the protein-binding method of Gilman (1970). The mean CSF cAMP concentration (22.4 plus or minus 0.6 (S.E.) nmol/l) of 24 "healthy" children tended to be lower (P less then 0.2) than that of adult patients who revealed no pathological findings on clinical examination. No difference in the results was foung between the sexes. High cAMP concentrations were found in CSF of children suffering from cerebellar glioma, hypothalamic precocious puberty, bacterial meningitis, or Cushing's disease. The urinary excretion of cAMP varied from 0.2 to 5.3 in "healthy" and from 1.3 to 7.6 mumol/24 hrs in diseased children. Two children with pheochromocytoma showed a striking decrease in the rate of urinary excretion of the nucleotide after surgical treatment.
Links	PubMed
Keywords	Abnormalities, Multiple; Adolescent; Cartilage; Cerebellar Neoplasms; Child; Child, Preschool; Cushing Syndrome; Cyclic AMP; Encephalitis; Female; Hair; Humans; Hydrocephalus; Infant; Infant, Newborn; Male; Medulloblastoma; Meningitis, Meningococcal; Pheochromocytoma; Puberty, Precocious
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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
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