PMID:227838
| Citation |
Alderman, EM , Dills, SS , Melton, T and Dobrogosz, WJ (1979) Cyclic adenosine 3',5'-monophosphate regulation of the bacteriophage T6/colicin K receptor in Escherichia coli. J. Bacteriol. 140:369-76 |
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| Abstract |
Mutant strains of Escherichia coli unable to synthesize cyclic adenosine 3',5'-monophosphate (cAMP) or the cyclic adenosine monophosphate receptor protein (CRP) were more resistant than wild-type cells to infection by bacteriophage T6. This resistance was found to be associated with the decreased production of specific T6 receptor protein (also the colicin K receptor) located in the outer membrane protein fraction of these cells. Transcription of this particular outer membrane protein was regulated by the cAMP-CRP complex. A novel affinity technique coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis was used in these investigations. |
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| Keywords |
Bacterial Proteins/biosynthesis; Colicins; Cyclic AMP/physiology; Escherichia coli/metabolism; Mutation; Receptors, Cyclic AMP/physiology; Receptors, Drug/biosynthesis; Receptors, Virus/biosynthesis; Transcription, Genetic |
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Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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Resistance to Phage T6. Table 3. |
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a mutation or genetic difference within a strain |
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Resistance to Phage T6. Table 3. |
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Notes
OMPID: Make Annotation for phage resistance. Then we need to make some kind of marker for it being specifically T6 (do we keep it in the comments/ntoes section?)
ECOID: ???
References
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