PMID:352805
| Citation |
Shakulov, RS, Livshits, VA, Zaigraeva, GG, Lideman, LF and Mukhamed'ianova, TD (1978) [Partial suppression of the effect of gene re1A in Fusr-mutant Escherichia coli K-12 cells]. Genetika 14:890-9 |
|---|---|
| Abstract |
Mutants of Escherichia coli K-12 re1A+-strain CP 78 resistant to fusidic acid (Fusr) were isolated and forms sensitive to high concentration of leucine (500 g/ml) were selected. When shifted down from nutrient broth to minimal medium M9 with supplemented glucose and required amino acids, these leucine-sensitive mutants continued RNA synthesis and demonstrated the prolonged lag-phase in contrast to the parent strain CP 78. Both properties are known to be characteristic of the Rel- strains. At the same time withdrawal of the required amino acids results in cessation of RNA synthesis in Fusr mutants, in the parent Rel+ strain. Thus, leucine-sensitive Fusr mutants show Rel- phenotype only upon amino acid starvation caused by shift down from nutrient broth to minimal medium. |
| Links | |
| Keywords |
Adaptation, Physiological; Bacterial Proteins/biosynthesis; Drug Resistance, Microbial; Escherichia coli/drug effects; Escherichia coli/genetics; Fusidic Acid/pharmacology; Genes; Leucine/pharmacology; Mutation; RNA, Bacterial/biosynthesis |
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
See Help:AnnotationTable for details on how to edit this table.
<protect>
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
| edit table |
</protect>
Notes
References
See Help:References for how to manage references in omp dev.
