PMID:353502
| Citation |
Thorbjarnardóttir, SH, Magnúsdóttir, RA and Eggertsson, G (1978) Mutations determining generalized resistance to aminoglycoside antibiotics in Escherichia coli.Mol. Gen. Genet. 161:89-98 |
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| Abstract |
Mutations conferring resistance to low levels of kanamycin in Escherichia coli have been mapped at 3 locations: the unc locus (min. 83), a locus we have designated kanA (MIN. 72), close to strA (rpsL), and a locus at min. 86.5 previously discovered by Plate (1976) that we have designated ecfB. The unc and ecfB mutations are associated with defects in energy metabolism, while mutations at kanA may be in the gene coding for ribosomal protein S12 (rpsL). The three types of mutations cause cross resistance to a number of different aminoglycoside antibiotics and the effects of the mutations are cumulative in combination. |
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| Keywords |
Ampicillin; Chloramphenicol; Chromosome Mapping; Chromosomes, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Genes; Kanamycin; Penicillin Resistance; Tetracycline; Transduction, Genetic |
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Main Points of the Paper
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Materials and Methods Used
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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0000276 |
increased resistance to antimicrobial compound |
Resistance to 90 micrograms/ml Kanamycin . |
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Notes
ECOID: Term for Solid in vivo assay is awaiting approval and # assignment.
OMP term: Term is up for discussion in meeting awaiting for term request and eventually being assigned in the tree.
References
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