PMID:3906038
| Citation |
Hrebenda, J, Heleszko, H, Brzostek, K and Bielecki, J (1985) Mutation affecting resistance of Escherichia coli K12 to nalidixic acid.J. Gen. Microbiol. 131:2285-92 |
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| Abstract |
A new mutation, nalD, determining resistance of Escherichia coli to nalidixic acid (NAL) is reported. The nalD mutant described is resistant to NAL at 37 degrees C but sensitive at 30 degrees C. It is defective in penetration of NAL and glycerol through the outer membrane at 37 degrees C. The nalD mutation is located half-way between 89 and 89.5 min on the E. coli genetic map. |
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| Keywords |
Biological Transport; Cell Membrane Permeability; Chromosome Mapping; Conjugation, Genetic; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Mutation; Nalidixic Acid |
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Main Points of the Paper
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Materials and Methods Used
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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OMP:0000276 |
increased resistance to antibiotics |
ECO:0000182 |
in vitro culture assay data |
Mutant is resistant to Nalidixic acid (NAL) at 37C and sensitive at 30C |
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Notes
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