PMID:6344786
| Citation |
Jaffé, A, Chabbert, YA and Derlot, E (1983) Selection and characterization of beta-lactam-resistant Escherichia coli K-12 mutants.Antimicrob. Agents Chemother. 23:622-5 |
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| Abstract |
beta-Lactam-resistant mutants of Escherichia coli K-12 were selected by using 12 different beta-lactam derivatives. The mutants fell into three categories showing (i) altered permeation through reduction or loss of outer membrane porin proteins (including ompF, ompR, and envZ alleles); (ii) increase in the rate of synthesis of chromosomally mediated beta-lactamase; or (iii) defective synthesis or action of cyclic adenosine 3',5'-phosphate (cya and crp alleles). |
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| Keywords |
Anti-Bacterial Agents; Drug Resistance, Microbial; Escherichia coli; Mutation; beta-Lactamases; beta-Lactams |
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Main Points of the Paper
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Materials and Methods Used
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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OMP:0000276 |
increased resistance to antimicrobial compound |
Resistance to Beta Lactams |
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</protect>
Notes
References
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