PMID:6995450
| Citation |
Guth, A, Engel, R and Tropp, BE (1980) Uptake of glycerol 3-phosphate and some of its analogs by the hexose phosphate transport system of Escherichia coli.J. Bacteriol. 143:538-9 |
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| Abstract |
The hexose phosphate transport system transported glycerol 3-phosphate and its analogs 3,4-dihydroxybutyl-1-phosphonate, glyceraldehyde 3-phosphate, and 3-hydroxy-4-oxobutyl-1-phosphonate. |
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| Keywords |
Biological Transport; Butylene Glycols; Escherichia coli; Glyceraldehyde 3-Phosphate; Glycerophosphates; Hexosephosphates; Organophosphorus Compounds; Phosphonic Acids |
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Main Points of the Paper
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Materials and Methods Used
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
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Notes
- Due to the high rate of mutation of the glycerol 3-phosphate transport system the hexose phosphate transport system was used.
- The growth of strain T5-6 was inhibited by glycerol 3-phosphate and the analogs 3,4-dihydroxybutyl-1-phosphonate, glyceraldhyde 3-phosphate & 3-hydroxyl-4-oxobutyl-1-phosphonate; see figure 1.
- Stain 5-6 was found to be to be resistant to glycerol 3-phosphate and its three analogs
- T5-6 mutants resistant to fructose 1-phosphate were found to have similar resistant patterns as strain 5-6 to glycerol 3-phosphate and its 3 analogs.
- Of the 3 glycerol 3-phosphate recognizing systems the hexose phosphate transport system seems to have the broadest specificity though all 3 could prove useful in the search for drug resistant mutants.
References
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