PMID:780339
| Citation |
White, BJ, Hochhauser, SJ, Cintron, NM and Weiss, B (1976) Genetic mapping of xthA, the structural gene for exonuclease III in Escherichia coli K-12.J. Bacteriol. 126:1082-8 |
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| Abstract |
The genes xthA, pncA, and pabB were ordered relative to others by two- and three-factor transductional crosses with bacteriophage P1. The genes studied span 2 min (2%) of the genetic map of Escherichia coli K-12 in the clockwise sequence pheS-pfkB-xthA-pncA-gap-pabB-fadD. Eleven independently derived xth mutations were examined; all were known to affect exonuclease III and its associated endonuclease II activity, and all were mapped in the xthA region. pncA mutations were found to confer resistance to 6-aminonicotinamide, whereas some pheS mutations are known to specify resistance to p-fluorphenylalanine. xth mutations were readily transferred into other strains by selecting for these co-transducible drug resistance markers. |
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| Keywords |
6-Aminonicotinamide; Chromosome Mapping; Deoxyribonucleases; Drug Resistance, Microbial; Endonucleases; Escherichia coli; Exonucleases; Genes; Transduction, Genetic; p-Fluorophenylalanine |
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Main Points of the Paper
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Materials and Methods Used
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Phenotype Annotations
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| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
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a mutation or genetic difference within a strain |
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OMP:0000276 |
increased resistance to antibiotics |
ECO:0000034 |
non-traceable author statement |
Resistant to 6-amino-nicotinamide |
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Notes
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